173456-48-9

Basic information

• Product Name: 7-{4-[4-(4-Benzyloxy-2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one
• Synonyms: 7-{4-[4-(4-Benzyloxy-2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one
• CAS NO: 173456-48-9
• Molecular Weight: 554.516
• Mol File: 173456-48-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-{4-[4-(4-Benzyloxy-2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-{4-[4-(4-Benzyloxy-2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one(173456-48-9)
• EPA Substance Registry System: 7-{4-[4-(4-Benzyloxy-2,3-dichloro-phenyl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-quinolin-2-one(173456-48-9)

Safety Data

• Hazardous Substances Data: 173456-48-9(Hazardous Substances Data)

Upstream product

• 576-24-9 2,3-dichlorophenol 
• 1940-44-9 4-bromo-2,3-dichlorophenol 
• 120004-79-7 7-(4-chlorobutoxy)-3,4-dihydroquinoline-2(1H)-one 
• 173456-54-7 1-(4-benzyloxy-2,3-dichlorophenyl)piperazine 
• 173456-52-5 2,3-dichloro-4-benzyloxynitrobenzene 
• 207238-25-3 3-benzyloxy-4-bromo-1,2-dichlorobenzene 
• 173456-53-6 4-(benzyloxy)-2,3-dichloroaniline 
• 207238-21-9 Carbonic acid 2,3-dichloro-phenyl ester ethyl ester 
• 59384-57-5 4-nitro-2,3-dichlorophenol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 

Relevant articles and documents

Practical application of the palladium-catalyzed amination in phenylpiperazine synthesis: An efficient synthesis of a metabolite of the antipsychotic agent aripiprazole

A metabolite of Aripiprazole (1), 7-[4-[4-(2,3-dichloro-4- hydroxyphenyl)-1-piperaziyl]butoxy]-3,4-dihydro-2(1H)-quinolinone (2), was prepared by the coupling reaction of 1-(4-benzyloxy-2,3-dichlorophenyl) piperazine (11) with 7-(4-chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone (16). The palladium-catalyzed amination of contiguous tri- and tetra-substituted benzenes with piperazine derivatives was investigated. The key intermediate 11 was efficiently prepared using the palladium-catalyzed amination of phenyl bromide 15 with piperazine.