1735-84-8 Usage
Description
3-Chloro-2,4,5,6-tetrafluoropyridine, also known as 3-chlorotetrafluoropyridine, is a fluoropyridine derivative characterized by the presence of four fluorine atoms and a chlorine atom on the pyridine ring. It exhibits a clear, colorless liquid state and has been studied through quantum mechanical calculations of energies, geometries, and vibrational wave numbers using the DFT level of theory. Its FT-IR and FT-Raman spectra have been interpreted, and it can form corresponding organo-zinc compounds by reacting with zinc. Additionally, it can react with tris(diethylamino)phosphine (P(NEt)3) in the presence of a proton donor to form a product with fluorine replaced by hydrogen at position 4.
Uses
Used in Pharmaceutical Industry:
3-Chloro-2,4,5,6-tetrafluoropyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of various diseases and disorders. Its unique structure and reactivity make it a valuable building block for the development of new drugs.
Used in Chemical Research:
As a fluoropyridine derivative, 3-chlorotetrafluoropyridine is utilized in chemical research for the investigation of its properties and potential applications. Its reactivity with different reagents, such as zinc and tris(diethylamino)phosphine, allows for the exploration of new chemical reactions and the development of novel compounds.
Used in Material Science:
3-Chloro-2,4,5,6-tetrafluoropyridine can be employed in the development of new materials with specific properties, such as those with enhanced stability, reactivity, or selectivity. Its unique structure and ability to form organo-zinc compounds make it a promising candidate for use in material science applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1735-84-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1735-84:
(6*1)+(5*7)+(4*3)+(3*5)+(2*8)+(1*4)=88
88 % 10 = 8
So 1735-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H3F7O/c1-3(2(6)13,4(7,8)9)5(10,11)12/h1H3
1735-84-8Relevant articles and documents
Banks, R. E.,Haszeldine, R. N.,Latham, J. V.,Young, I. M.
, (1965)
Preparation method of 4-aminopyridine compound
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, (2021/02/06)
The invention discloses a preparation method of a 4-aminopyridine compound. The preparation method comprises the following steps: adding a 4-amino- 3-chloropyridine compound or a 4-amino-3, 5-dichloropyridine compound, potassium phosphate and a catalyst into a solvent, and reacting at 0-10 MPa and 0-100 DEG C for 4-12 hours. According to the preparation method of the 4-aminopyridine compound, therelated raw materials are easy to obtain or self-make, the cost is low, the preparation method is simple, the reaction efficiency is high, the raw material cost is low, and byproducts have economic value; meanwhile, the reaction involved in the invention has good universality and tolerance to functional groups.
METHOD FOR PRODUCING A COMPOUND CONTAINING FLUORINE VIA FLUORINE-HALOGEN EXCHANGE BY SPECIAL POLYAMINO PHOSPHAZENE CATALYSTS
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Page 20, (2008/06/13)
The invention relates to a method for producing compounds containing fluorine by reacting a compound, which contains hydrogen that can be exchanged for fluorine, with a fluoride or with a mixture of fluorides of general formula (I): MeF, wherein Me represents an alkaline earth metal ion, an NH4+ ion or an alkali metal ion, in the presence or absence of a solvent at a temperature ranging from 60 to 260 °C. The invention is characterized in that the reaction is carried out in the presence of a compound or of a mixture of compounds of general formula (IIa) and/or (IIb), whereby X1 and/or X2 and/or X3, independent of one another, have groups of formula (llc) or other groups cited in the claims.
POLYHALOAROMATIC EQUILIBRATIONS
Weigert, F. J.
, p. 33 - 42 (2007/10/02)
Chromium oxide is a good catalyst for scrambling halogens among polyhaloaromatic compounds.Chloropentafluorobenzene and bromopentafluorobenzene disproportionate to hexafluorobenzene and the respective tetrafluorodihalobenzenes.Pentachloro- and pentafluoropyridines produce pyridines with intermediate numbers of both types of halogens.Cyano, trifluoromethyl and a single hydrogen can be present on the aromatic rings without interfering with the chemistry.
