173776-65-3

Basic information

• Product Name: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate
• Synonyms: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate
• CAS NO: 173776-65-3
• Molecular Weight: 328.343
• Mol File: 173776-65-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate(173776-65-3)
• EPA Substance Registry System: dimethyl 2-<2-<4-(methylsulfonyl)phenyl>-2-oxoethyl>propanedioate(173776-65-3)

Safety Data

• Hazardous Substances Data: 173776-65-3(Hazardous Substances Data)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 50413-24-6 2-bromo-1-(4-methanesulfonylphenyl)ethanone 
• 21382-98-9 p-cyanophenyl methyl sulfide 
• 10297-73-1 4-(methanesulfonyl)acetophenone 
• 1778-09-2 4-(Methylthio)acetophenone 

Downstream Products

• 1027900-87-3 2-[2-(2,4-Difluoro-phenyl)-2-oxo-ethyl]-2-[2-(4-methanesulfonyl-phenyl)-2-oxo-ethyl]-malonic acid dimethyl ester 
• 1025875-04-0 C₃₅H₃₃F₃O₉S₃ 
• 1025947-41-4 C₃₅H₃₅FO₉S₃ 
• 1026923-41-0 C₃₅H₃₄O₁₀S₃ 
• 1027150-18-0 C₃₅H₃₃F₃O₈S₃ 
• 1027988-15-3 C₃₅H₃₅BrO₉S₃ 
• 173776-70-0 C₃₅H₃₅ClO₉S₃ 
• 1026974-83-3 C₃₄H₃₂ClFO₈S₃ 
• 1026491-58-6 C₃₄H₃₂F₂O₈S₃ 
• 1027021-74-4 C₃₄H₃₂F₂O₈S₃ 
• 1027925-41-2 C₃₅H₃₆O₈S₃ 
• 1027162-88-4 3-(4-Methanesulfonyl-phenyl)-4-(4-trifluoromethoxy-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid dimethyl ester 
• 1025927-52-9 3-Benzo[1,3]dioxol-5-yl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid dimethyl ester 
• 1025916-25-9 1-[2-(4-trifluoromethylphenyl)-4,4-dicarbomethoxycyclopenten-1-yl]-4-(methylsulfonyl)benzene 

Relevant articles and documents

Efficient syntheses of 2-(3',5'-difluorophenyl)-3-(4'- methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor

2-(3',5'-Difluorophenyl)-3-(4'-methylsulfonylphenyl)cyclopent-2-enone (1) displays high selectivity and potency against COX-2. Three efficient syntheses of this diarylcyclopentenone are described. The first approach employs a Suzuki coupling reaction as the key step while the second synthesis features an intramolecular Friedel-Crafts acylation. The third, and preferred route to this compound involves a sequential malonate alkylation and acylation and ring-closure sequence.