174264-47-2

Basic information

• Product Name: 6-tert-Butyldimethylsilyl-4’-hydroxy Raloxifene
• Synonyms: 6-tert-Butyldimethylsilyl-4’-hydroxy Raloxifene;[6-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]Methanone;6-tert-Butyldimethylsilyl-4a€-hydroxy Raloxifene
• CAS NO: 174264-47-2
• Molecular Formula: C₃₄H₄₁NO₄SSi
• Molecular Weight: 587.84414
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 174264-47-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 706.195°C at 760 mmHg
• Flash Point: 380.893°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: -20?C Freezer
• Solubility: Acetone, Chloroform, Dichloromethane, Ethanol, Methanol
• CAS DataBase Reference: 6-tert-Butyldimethylsilyl-4’-hydroxy Raloxifene(CAS DataBase Reference)
• NIST Chemistry Reference: 6-tert-Butyldimethylsilyl-4’-hydroxy Raloxifene(174264-47-2)
• EPA Substance Registry System: 6-tert-Butyldimethylsilyl-4’-hydroxy Raloxifene(174264-47-2)

Safety Data

• Hazardous Substances Data: 174264-47-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

InChI:InChI=1/C34H41NO4SSi/c1-34(2,3)41(4,5)39-28-17-18-29-30(23-28)40-33(25-9-13-26(36)14-10-25)31(29)32(37)24-11-15-27(16-12-24)38-22-21-35-19-7-6-8-20-35/h9-18,23,36H,6-8,19-22H2,1-5H3

Upstream product

• 84449-90-1 Raloxifen 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 82640-04-8 raloxifene hydrochloride 

Downstream Products

• 185416-87-9 Trifluoro-methanesulfonic acid 4-{6-(tert-butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl ester 
• 174264-48-3 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-{6-(tert-butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 185416-94-8 4-{6-Hydroxy-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzoic acid methyl ester 
• 182507-22-8 Raloxifene-4'-beta-glucuronide 
• 1025925-22-7 [6-(tert-Butyl-dimethyl-silanyloxy)-2-(4-vinyl-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone 
• 1026314-83-9 1-(4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-ethanone 
• 1025845-03-7 4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-N,N-dimethyl-benzamide 
• 1027485-30-8 (4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-phenyl)-phosphonic acid diethyl ester 
• 185417-15-6 4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-N-methyl-benzamide 
• 185416-95-9 4-{6-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-2-yl}-benzoic acid methyl ester 

Relevant articles and documents

LYMPH DIRECTING PRODRUGS

H:\dar\Interwoven\NRPortbl\DCC\DAR\8230712_1.doc-12/08/2015 Abstract The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

Synthesis and estrogen receptor binding affinities of the major human metabolites of raloxifene (LY139481)

Glucuronide conjugates 1 and 2, the major metabolites of raloxifene, have been prepared and their molecular interactions with the estrogen receptor determined.