174363-91-8

Basic information

• Product Name: 2-{[2-(4-tert-Butoxy-3-tert-butoxycarbonylamino-butyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
• Synonyms: 2-{[2-(4-tert-Butoxy-3-tert-butoxycarbonylamino-butyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS NO: 174363-91-8
• Molecular Weight: 687.961
• Mol File: 174363-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-{[2-(4-tert-Butoxy-3-tert-butoxycarbonylamino-butyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[2-(4-tert-Butoxy-3-tert-butoxycarbonylamino-butyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester(174363-91-8)
• EPA Substance Registry System: 2-{[2-(4-tert-Butoxy-3-tert-butoxycarbonylamino-butyl)-5-decyl-phenyl]-methyl-amino}-3-methyl-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester(174363-91-8)

Safety Data

• Hazardous Substances Data: 174363-91-8(Hazardous Substances Data)

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 60902-45-6 nonyltriphenylphosphonium bromide 
• 174363-86-1 2-(tert-butoxycarbonylamino)-3-tert-butoxypropanal 
• 174363-87-2 methyl 2-(tert-butoxycarbonylamino)-3-tert-butoxypropanoate 
• 174363-88-3 [3-(2-Amino-4-decyl-phenyl)-1-tert-butoxymethyl-propyl]-carbamic acid tert-butyl ester 
• 174363-89-4 [1-tert-Butoxymethyl-3-(4-decyl-2-methylamino-phenyl)-propyl]-carbamic acid tert-butyl ester 
• 174511-54-7 [(Z)-1-tert-Butoxymethyl-3-(4-formyl-2-nitro-phenyl)-allyl]-carbamic acid tert-butyl ester 
• 174511-55-8 [(E)-1-tert-Butoxymethyl-3-(4-formyl-2-nitro-phenyl)-allyl]-carbamic acid tert-butyl ester 
• 155526-54-8 [(Z)-1-tert-Butoxymethyl-3-(4-[1,3]dioxolan-2-yl-2-nitro-phenyl)-allyl]-carbamic acid tert-butyl ester 
• 155526-55-9 [(E)-1-tert-Butoxymethyl-3-(4-[1,3]dioxolan-2-yl-2-nitro-phenyl)-allyl]-carbamic acid tert-butyl ester 
• 155526-66-2 (R)-methyl 2-(benzyloxycarbonylamino)-3-t-butoxypropanoate 
• 155526-65-1 4-(bromomethyl)-3-nitrobenzaldehyde 
• 155526-51-5 2-(4-Bromomethyl-3-nitro-phenyl)-[1,3]dioxolane 

Relevant articles and documents

Synthesis, conformation, and biological activity of teleocidin mimics, benzolactams. A clarification of the conformational flexibility problem in structure-activity studies of teleocidins

Tumor-promoter teleocidins and their active congeners (indolactams) are known to exist in an equilibrium between at least two conformational states in solution, the twist and sofa form, due to cis-trans isomerization of the amide bond and the steric effects of substituents on the nine-membered lactam ring. Benzolactam-Vs, in which the indole ring of indolactams is replaced with a benzene ring, were designed and synthesized in an attempt to reproduce the active conformation of teleocidins. Among these benzolactams, eight-membered lactams (benzolactam-V8) can only exist in the twist form, and 9- and 10-membered lactams (benzolactam-V9 and -V10) exist exclusively in the sofa form in solution. The stronger biological activity of benzolactam-V-8-310 than that of indolactam-V (IL-V) and the inactivity of benzolactam-V-9-310 for differentiation inducing activity of HL-60 clearly indicated that the twist form is close to the active conformation of teleocidins.