17478-44-3

Basic information

• Product Name: 2-BROMO-4'-METHOXYPHENYL ACETIC ACID
• Synonyms: ALPHA-BROMO-(4-METHOXYPHENYL) ACETIC ACID METHYL ESTER;2-broMo-2-(4-Methoxyphenyl)acetic acid;(4-methoxyphenyl)bromoacetic acid;α-Bromo-4′-methoxyphenyl acetic acid
• CAS NO: 17478-44-3
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.07
• Mol File: 17478-44-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 157.7°C
• Appearance: /
• Density: 1.583g/cm³
• Vapor Pressure: 4.17E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-BROMO-4'-METHOXYPHENYL ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4'-METHOXYPHENYL ACETIC ACID(17478-44-3)
• EPA Substance Registry System: 2-BROMO-4'-METHOXYPHENYL ACETIC ACID(17478-44-3)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 17478-44-3(Hazardous Substances Data)

Usage

General Description

2-Bromo-4'-methoxyphenyl acetic acid is a chemical compound with the molecular formula C9H9BrO3. It is a derivative of acetic acid and belongs to the class of phenyl acetic acid compounds. This chemical contains a bromine and a methoxy group attached to a phenyl ring. It is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its potential as a building block in organic chemistry. Additionally, 2-Bromo-4'-methoxyphenyl acetic acid has shown potential as an anti-inflammatory agent in scientific studies. Its chemical structure and properties make it valuable in the development of new drugs and materials.

InChI:InChI=1/C9H9BrO3/c1-13-7-4-2-6(3-5-7)8(10)9(11)12/h2-5,8H,1H3,(H,11,12)

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 43091-16-3 2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-thiazolo[3,2-a]pyridinylium betaine 
• 92552-87-9 2-(4-methoxy-phenyl)-4H-benzo[1,4]thiazin-3-one 
• 75288-22-1 2-bromo-2-(4-methoxyphenyl)acetyl chloride 
• 91012-98-5 (4-methoxyphenyl)(methylamino)acetic acid 
• 52705-21-2 dimethyl 1-methyl-2-(4-methoxyphenyl)pyrrole-3,4-dicarboxylate 
• 104156-62-9 1-methyl-2-(4-methoxyphenyl)-3,4-bis(hydroxymethyl)pyrrole 
• 104156-63-0 1-methyl-2-(4-methoxyphenyl)-3,4-bis<<(N-2-propylcarbamoyl)oxy>methyl>pyrrole 
• 29703-24-0 4-(2-diethylamino-ethyl)-2-(4-methoxy-phenyl)-4H-benzo[1,4]thiazin-3-one 
• 251366-54-8 α-bromo-(4-methoxyphenyl)acetamide 
• 251366-32-2 2-bromo-2-(p-fluorophenyl)acetamide 
• 1233941-60-0 5-(4-methoxyphenyl)-2-(pyrazin-2-yl)-1,3-thiazol-4-ol 
• 1239919-77-7 (2R,4R)-4-hydroxypentan-2-yl 2-bromo-2-(4-methoxyphenyl)acetate 
• 1239919-83-5 (2S,4R)-4-hydroxypentan-2-yl 2-bromo-2-(4-methoxyphenyl)acetate 
• 887642-32-2 N-benzyl-2-hydroxy-2-(4-methoxyphenyl)acetamide 

Relevant articles and documents

A metal-free and mild approach to 1,3,4-oxadiazol-2(3: H)-ones via oxidative C-C bond cleavage using molecular oxygen

A mild metal-free approach to 1,3,4-oxadiazol-2(3H)-ones via 1,3,4-oxadiazin-5(6H)-ones is described. This novel transformation, promoted by the electron-withdrawing p-substituents on the phenyl group at the α-carbonyl position, features a tandem reaction consisting of oxidative hydroxylation and C-C bond cleavage using molecular oxygen. The method utilizes K2CO3 in CH3CN without any oxidants, transition metals, or additives, enabling the tunable synthesis of 1,3,4-oxadiazin-5(6H)-ones, 1,3,4-oxadiazol-2(3H)-ones, and α-ketoamides under mild aerobic conditions.

Optimized Diazo Scaffold for Protein Esterification

The O-alkylation of carboxylic acids with diazo compounds provides a means to esterify carboxylic acids in aqueous solution. A Hammett analysis of the reactivity of diazo compounds derived from phenylglycinamide revealed that the (p-methylphenyl)-glycinamide scaffold has an especially high reaction rate and ester/alcohol product ratio and esterifies protein carboxyl groups more efficiently than any known reagent. (Chemical Equation Presented).

Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)

A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.