17509-54-5

Basic information

• Product Name: 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID
• Synonyms: ART-CHEM-BB B013941;CHEMBRDG-BB 3013941;2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID;AKOS B013941;2-(4-methoxyphenoxy)-2-methylpropanoic acid;2-(4-methoxyphenoxy)-2-methylpropanoic acid(SALTDATA: FREE);Propanoic acid, 2-(4-Methoxyphenoxy)-2-Methyl-
• CAS NO: 17509-54-5
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol File: 17509-54-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 128.8°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 4.16E-05mmHg at 25°C
• Refractive Index: 1.517
• CAS DataBase Reference: 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID(17509-54-5)
• EPA Substance Registry System: 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID(17509-54-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 17509-54-5(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxy-phenoxy)-2-methyl-propionic acid is a chemical compound with the molecular formula C12H14O4. It is a derivative of propionic acid and contains a methoxy group and a methyl group attached to a phenoxy ring. 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID is commonly used in the pharmaceutical industry as a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. It is also used as a potential candidate for the treatment of chronic pain and inflammatory disorders. Additionally, it has been studied for its potential use in the treatment of various other conditions such as migraine, dysmenorrhea, and rheumatoid arthritis.

InChI:InChI=1/C11H14O4/c1-11(2,10(12)13)15-9-6-4-8(14-3)5-7-9/h4-7H,1-3H3,(H,12,13)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 67-64-1 acetone 
• 57-15-8 1,1,1-trichloro-2-methyl-2-propanol 
• 2052-01-9 2-bromo-2-methylpropionic acid 
• 1877-75-4 2-(4-methoxyphenoxy)acetic acid 
• 13794-15-5 2-(4-methoxyphenoxy)propanoic acid 
• 111479-08-4 ethyl 2-(4-methoxyphenoxy)propanoate 
• 67-66-3 chloroform 

Downstream Products

• 18672-05-4 α-(4-methoxy-phenoxy)-isobutyric acid ethyl ester 
• 4878-04-0 2-(4-Methoxy-phenoxy)-2-methyl-propionyl chloride 
• 65110-04-5 3,3-dimethyl-1,4-dioxospiro[4.5]deca-6,9-diene-2,8-dione 
• 150-76-5 4-methoxy-phenol 
• 106-51-4 p-benzoquinone 
• 443126-41-8 3,3-dimethyl-8,8-dimethoxy-1,4-dioxaspiro[4.5]deca-6,9-dien-2-one 
• 935-50-2 4,4-dimethoxycyclohexa-2,5-dienone 
• 116762-27-7 2-(4-methoxyphenoxy)-2-methyl-propionyl-cyanomethylenetriphenylphosphorane 

Relevant articles and documents

Discovery of adamantane ethers as inhibitors of 11β-HSD-1: Synthesis and biological evaluation

A novel class of adamantane ethers 11β-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure-activity relationships, selectivity, metabolism, PK, ex vivo

Pd(II)-catalyzed ortho - Or meta-C-H olefination of phenol derivatives

A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives. These reactions demonstrate the feasibility of directing C-H functionalizations when functional groups are distal to target C-H bonds. The meta-C-H functionalization of electron-rich phenol derivatives is unprecedented and orthogonal to previous electrophilic substitution of phenols in terms of regioselectivity. These methods are also applied to functionalize α-phenoxyacetic acids, a fibrate class of drug scaffolds.

Improved method for the synthesis of 2-methyl-2-aryloxypropanoic acid derivatives

An improved method for the formation of 2-methyl-2-aryloxypropanoic acid derivatives, an important class of compounds for the potential treatment of type II diabetes, is reported. This method offers several advantages over the existing chemistry for this transformation.