175137-51-6

Basic information

• Product Name: 2-(2-CHLOROBENZOYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE
• Synonyms: 2-(2-CHLOROBENZOYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE;3,3-BIS(METHYLTHIO)-2-(2-CHLOROBENZOYL)ACRYLONITRILE
• CAS NO: 175137-51-6
• Molecular Formula: C₁₂H₁₀ClNOS₂
• Molecular Weight: 283.7969
• Mol File: 175137-51-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-CHLOROBENZOYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLOROBENZOYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE(175137-51-6)
• EPA Substance Registry System: 2-(2-CHLOROBENZOYL)-3,3-DI(METHYLTHIO)ACRYLONITRILE(175137-51-6)

Safety Data

• Hazardous Substances Data: 175137-51-6(Hazardous Substances Data)

Usage

Physical state

Yellow solid

Usage

Synthesis of various organic compounds

Known for

Unique structure and reactivity

Applications

Production of pharmaceuticals, agrochemicals, specialty chemicals, dyes, and pigments

Importance

Versatile properties and applications, key intermediate in manufacturing dyes and pigments, valuable in the field of organic chemistry.

Upstream product

• 75-15-0 carbon disulfide 
• 40018-25-5 2-Chlorobenzoyl acetonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 180904-22-7 (Z)-2-(2-Chloro-benzoyl)-3-(3-methoxy-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 180904-28-3 (Z)-2-(2-Chloro-benzoyl)-3-(2,4-dichloro-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 180904-29-4 (Z)-2-(2-Chloro-benzoyl)-3-methylsulfanyl-3-(3-trifluoromethyl-phenylamino)-acrylonitrile 
• 180904-26-1 (Z)-2-(2-Chloro-benzoyl)-3-(4-chloro-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 180904-21-6 (Z)-2-(2-Chloro-benzoyl)-3-(4-methoxy-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 67985-36-8 (Z)-2-(2-Chloro-benzoyl)-3-methylsulfanyl-3-phenylamino-acrylonitrile 
• 180904-24-9 (Z)-2-(2-Chloro-benzoyl)-3-methylsulfanyl-3-o-tolylamino-acrylonitrile 
• 180904-27-2 (Z)-2-(2-Chloro-benzoyl)-3-(4-fluoro-phenylamino)-3-methylsulfanyl-acrylonitrile 
• 180904-25-0 (Z)-3-(4-Bromo-phenylamino)-2-(2-chloro-benzoyl)-3-methylsulfanyl-acrylonitrile 
• 67985-40-4 2-methylsulfanyl-4-oxo-1-phenyl-1,4-dihydro-quinoline-3-carbonitrile 
• 78816-82-7 3-Amino-9-phenyl-1H-pyrazolo<3,4-b>chinolin-4(9H)-on 
• 180904-33-0 2-Methylsulfanyl-4-oxo-1-o-tolyl-1,4-dihydro-quinoline-3-carbonitrile 
• 180904-35-2 1-(4-Chloro-phenyl)-2-methylsulfanyl-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 180904-34-1 1-(4-Bromo-phenyl)-2-methylsulfanyl-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 

Relevant articles and documents

Synthesis and activity of some quinolone derivatives against Plasmodium falciparum in vitro

Quinolones 7a-i and 8a-i were synthesized and tested in vitro as antimalarial against Plasmodium falciparum in chloroquine resistant strain. The above compounds were inactive at concentrations of 1.0 x 10-4 M except the quinolone 3-amino-9-(2,4-dichlorophenyl)-1H-pyrazolo[3,4-b]-4-quinolone 7h which showed IC50 of 5.06 μM given the most interesting results.