175178-82-2 Usage
Description
AG 1478, also known as Tyrphostin AG 1478, is a potent and selective inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase. It is characterized by its high potency and specificity, with an IC50 value of 3 nM. AG 1478 is cell permeable and has been shown to inhibit the proliferation of various human cancer cell lines. It is also effective in reducing pulmonary fibrosis in a rat model.
Uses
Used in Pharmaceutical Research:
AG 1478 is used as an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for studying its effect on desmoid cell mobility in Boyden chamber motility assays. It is particularly useful in investigating the role of EGFR in cell signaling and its potential as a therapeutic target for various diseases.
Used in Cancer Research:
AG 1478 is used as a potent and selective inhibitor of EGFR to inhibit the phosphorylation of c-Met by exogenous transforming growth factor α in the epidermoid carcinoma cell line A431. This application helps researchers understand the role of EGFR in cancer cell proliferation and the potential of AG 1478 as an anticancer agent.
Used in Cell Signaling Studies:
AG 1478 is used as a research tool to study the role of EGFR in various cellular processes, including cell proliferation, migration, and survival. Its high potency and selectivity make it an ideal compound for investigating the molecular mechanisms underlying these processes.
Used in Drug Development:
AG 1478 is used as a lead compound in the development of new drugs targeting the EGFR pathway. Its potent inhibition of EGFR tyrosine kinase activity and its cell permeability make it a promising starting point for the design of new therapeutic agents for cancer and other diseases involving the EGFR pathway.
Used in Pulmonary Fibrosis Research:
AG 1478 is used as a therapeutic agent to reduce pulmonary fibrosis in rat models. Its ability to inhibit EGFR activity may provide insights into the potential treatment of pulmonary fibrosis and other fibrotic diseases.
Biochem/physiol Actions
Primary TargetEpidermal growth factor receptor kinase
References
1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859
2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379
3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213
Check Digit Verification of cas no
The CAS Registry Mumber 175178-82-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,1,7 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 175178-82:
(8*1)+(7*7)+(6*5)+(5*1)+(4*7)+(3*8)+(2*8)+(1*2)=162
162 % 10 = 2
So 175178-82-2 is a valid CAS Registry Number.
