17554-22-2Relevant articles and documents
Phosphorus pentoxide for amide and peptide bond formation with minimal by-products
Erapalapati, Venkataramana,Hale, Umatai A.,Madhavan, Nandita
supporting information, (2019/11/21)
Phosphorus pentoxide and DMAP are used for amide bond formation from carboxylic acids and amines. Dipeptides and amides have been synthesized using this reagent in 42–77% yields and >99% ees. The protocol is attractive as it occurs at ambient temperature, the formation of organic by-products is minimal and the reagent can be readily quenched using water. Furthermore, excellent enantioselectivities are observed without the use of harsh triazole based additives.
ONE-STEP STEREOSPECIFIC SYNTHESIS OF α,β-DEHYDROAMINO ACIDS AND DEHYDROPEPTIDES
Berti, Federico,Ebert, Cynthia,Gardossi, Lucia
, p. 8145 - 8148 (2007/10/02)
Dehydroamino acids and dehydropeptides were prepared by a one-pot reaction employing diethyl chlorophosphate in the presence of sodium hydride.The reaction is stereospecific and proceeds without racemization.