17556-18-2

Basic information

• Product Name: 6-Chloro-2-tetralone
• Synonyms: 6-CHLORO-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE;6-CHLORO-2-TETRALONE;6-Chloro-3,4-dihydro-2(1H)-naphthalenone;6-Chloro-3,4-dihydronaphthalen-2(1H)-one;2(1H)-Naphthalenone, 6-chloro-3,4-dihydro-;6-chloro-1,2,3,4-tetrahydronaphthalen-2-one;6-Chlorotetralin-2-one
• CAS NO: 17556-18-2
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63
• Product Categories: pharmacetical
• Mol File: 17556-18-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 60-65 °C(lit.)
• Boiling Point: 304.612 °C at 760 mmHg
• Flash Point: 145.219 °C
• Appearance: /
• Density: 1.248 g/cm³
• Vapor Pressure: 0.000865mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 6-Chloro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-2-tetralone(17556-18-2)
• EPA Substance Registry System: 6-Chloro-2-tetralone(17556-18-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 37/39
• WGK Germany: 3
• Hazardous Substances Data: 17556-18-2(Hazardous Substances Data)

Usage

General Description

6-Chloro-2-tetralone is a chemical compound with the molecular formula C10H9ClO. It is a chlorinated derivative of 2-tetralone, which is a bicyclic ketone compound. 6-Chloro-2-tetralone is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has various applications in the field of organic chemistry, including as a building block for the preparation of heterocyclic compounds and in the development of new drugs. This chemical is also used in research and development in the pharmaceutical industry and may have potential applications in medicine and agriculture.

InChI:InChI=1/C10H9ClO/c11-9-3-1-8-6-10(12)4-2-7(8)5-9/h1,3,5H,2,4,6H2

Upstream product

• 75693-22-0 6-Chlor-1,2-epoxy-tetralin 
• 74-85-1 ethene 
• 25026-34-0 4-chlorophenacetyl chloride 
• 1878-66-6 4-chlorophenylacetic Acid 
• 26673-31-4 6-chloro-3,4-dihydronaphthalen-1(2H)-one 
• 75693-16-2 6-chloro-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 75693-19-5 6-chloro-1,2-dihydronaphthalene 
• 1160858-18-3 C₁₂H₁₃ClO₄ 
• 1190847-97-2 C₁₄H₂₁ClO₃ 

Downstream Products

• 134697-65-7 1'-benzyl-6-chloro-3,4-dihydro-2-oxospiro 
• 148835-23-8 (6-Chloro-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 
• 87732-57-8 (S)-1-(3,4-Dihydro-6-chlor-2-naphthyl)-2-(methoxymethyl)pyrrolidin 
• 620171-73-5 1-benzyl-6-chlorotetralone 
• 148835-11-4 (6-Chloro-1-methyl-3,4-dihydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine 
• 134698-05-8 1'-benzyl-6-chloro-3,4-dihydrospiro(naphthalene-1-(2H),4'-piperidine) 
• 148835-22-7 8-Chloro-4-((S)-1-phenyl-ethyl)-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one 
• 146117-78-4 (+)-LY191704 
• 146117-78-4 bexlosteride 
• 148905-81-1 (-)-(4AR)-(10BR)-8-chloro-4-(S-α-methylbenzyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 148835-24-9 (+)-(4AS)-(10BS)-8-chloro-4-(S-α-methylbenzyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 146117-78-4 8-chloro-4-methyl-1,2,3,4,4a,5,6,10b-trans-octahydrobenzo-quinolin-3-one 
• 146117-78-4 8-chloro-4-methyl-1,2,3,4,4a,5,6,10b-cis-octahydrobenzo-quinolin-3-one 
• 6331-63-1 2-amino-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 

Relevant articles and documents

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with robust central efficacy. The reduction of brain Aβ in guinea pigs in the absence of changes in B-cells suggested a potential therapeutic index with respect to APP processing compared with biomarkers of notch related toxicity. Optimization of the FTOC to plasma concentrations at the brain Aβ EC50 lead to the identification of compound 14f (PF-3084014) which was selected for clinical development.

TiCl4-promoted intramolecular cyclization of 4-methoxy-5-arylethyl-1,3-dioxolan-2-ones: an expedient method to prepare 2-tetralones

DABCO is a very effective catalyst in the formation of 4-methoxy-5-arylethyl-1,3-dioxolan-2-ones 12 from the corresponding α-carbonatoaldehyde. Intramolecular cyclization of cyclic carbonates 12 promoted by TiCl4 affords 2-tetralones 13 contain

Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.