175881-22-8Relevant articles and documents
Synthesis of amino acid derivatives of 4-(1-adamantyl)benzoic acid obtained by transition metal ion catalyzed oxidation of 4-(1-adamantyl)toluene
Krasnikov, Sergey V.,Obuchova, Tatiana A.,Yasinskii, Oleg A.,Balakin, Konstantin V.
, p. 711 - 714 (2004)
An efficient synthesis of 4-(1-adamantyl)benzoic acid based on transition metal ion catalyzed oxidation of 4-(1-adamantyl)toluene has been developed. As a catalytic system, cobalt-manganese bromide with addition of manganese acetate was used. A series of
Synthesis and Evaluation of Nifurtimox–Adamantane Adducts with Trypanocidal Activity
Foscolos, Angeliki-Sofia,Papanastasiou, Ioannis,Tsotinis, Andrew,Taylor, Martin C.,Kelly, John M.
supporting information, p. 1227 - 1231 (2019/07/09)
The synthesis and pharmacological evaluation of C1-substituted adamantane hydrazones, their C2-substituted isomers, and C1-substituted adamantane furanoic carboxamides is described. These new adamantane derivatives exhibited an interesting pharmacological profile in terms of trypanocidal activity and selectivity. The most active adduct with the best selectivity in this study was found to be the phenylacetoxy hydrazone 1 b (2-[4-(tricyclo[3.3.1.13,7]dec-1-yl)phenyl]-N′-[(5-nitrofuran-2-yl)methylene]acetohydrazide; EC50=11±0.9 nm, SITb=770).
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail
Kasuga, Jun-ichi,Yamasaki, Daisuke,Ogura, Kiyoshi,Shimizu, Motomu,Sato, Mayumi,Makishima, Makoto,Doi, Takefumi,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 1110 - 1115 (2008/09/19)
3-(4-Alkoxyphenyl)propanoic acid derivatives were prepared as candidate peroxisome proliferator-activated receptor (PPAR) α/δ/γ pan agonists, based on our previous SAR studies directed toward the development of subtype-selective PPAR agonists. Those studi
