176433-43-5

Basic information

• Product Name: 6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE
• Synonyms: 6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE;2-Chloro-5-formyl-3-methylpyridine;6-Chloro-5-methylnicotinaldehyde;6-Chloro-5-Methylpyridine-3-carboxaldehyde;6-Chloro-5-methylpyridine-3-carboxaldehyde, 2-Chloro-5-formyl-3-methylpyridine;6-chloro-5-methyl-3-pyridinecarboxaldehyde
• CAS NO: 176433-43-5
• Molecular Formula: C₇H₆ClNO
• Molecular Weight: 155.58
• Product Categories: Building Blocks;Pyridine;organic building block
• Mol File: 176433-43-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 51-53°
• Boiling Point: 269.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.269±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.24±0.10(Predicted)
• CAS DataBase Reference: 6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE(176433-43-5)
• EPA Substance Registry System: 6-CHLORO-5-METHYLPYRIDINE-3-CARBALDEHYDE(176433-43-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 176433-43-5(Hazardous Substances Data)

Usage

General Description

6-Chloro-5-methylpyridine-3-carbaldehyde is a specific chemical compound with the molecular formula C7H6ClNO. It belongs to the family of Pyridines and derivatives in the group of Heterocyclic compounds. It appears as a white to off-white crystalline powder with a particular smell. The compound is noteworthy for its use in the chemistry and pharmaceutical industry. The chemical is used in a variety of biological and physiological research processes due to its varied applications. It's also employed in the synthesis of certain medicinal drugs. However, the precautions and handlers' safety mustn't be neglected because of potential hazards it could pose to the environment and health. Always consult the material safety data sheet (MSDS) for detailed information on handling, storage and disposal.

Upstream product

• 66909-33-9 2-chloro-5-cyano-3-methylpyridine 
• 4403-61-6 2-methyl-2-butene nitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 59782-89-7 2-Chloro-5-iodo-3-methylpyridine 
• 887707-21-3 (6-chloro-5-methylpyridin-3-yl)methanol 
• 30574-97-1 tiglonitrile 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 29241-60-9 5-bromo-2-chloro-3-methylpyridine 

Downstream Products

• 66909-29-3 6-chloro-5-methylpyridin-3-ylcarboxylic acid 
• 887707-21-3 (6-chloro-5-methylpyridin-3-yl)methanol 
• 942511-70-8 6-chloro-5-methylnicotinic acid ethyl ester 
• 1122090-09-8 isopropyl 6-chloro-5-methylnicotinate 
• 1122090-20-3 6-(Isopropylamino)-5-methylnicotinic acid 
• 1386986-16-8 5-difluoromethyl-3-methylpyridine-2-carboxylic acid 
• 1386986-17-9 2-chloro-5-difluoromethyl-3-methylpyridine 
• 1256791-13-5 1-(6-chloro-5-methyl-3-pyridyl)ethanone 
• 1413285-71-8 3-(6-chloro-5-methyl-3-pyridyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazole 
• 1413285-72-9 ethyl 2-[[5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-3-methyl-2-pyridyl]sulfanyl]acetate 
• 1516901-64-6 (S)-N-(3-(2-ethyl-4-(5-(6-isopropyl-5-methylpyridin-3-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 1186617-59-3 N-((S)-3-{4-[5-(6-diethylamino-5-methyl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide 
• 1186618-30-3 N-((S)-3-{2-ethyl-6-methyl-4-[5-(5-methyl-6-pyrrolidin-1-yl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]phenoxy}-2-hydroxypropyl)-2-hydroxyacetamide 
• 1186617-62-8 2-ethyl-6-methyl-4-[5-(5-methyl-6-pyrrolidin-1-yl-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-phenol 

Relevant articles and documents

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrates, such as hydrophilic fluoroquinolones, leading to a multidrug-resistance phenotype. In this work, approximately 150 heterocyclic boronic species were evaluated for their activity against susceptible and resistant strains of S. aureus. Twenty-four hit compounds, although inactive when tested alone, were found to potentiate ciprofloxacin activity by a 4-fold increase at concentrations ranging from 0.5 to 8 μg/mL against S. aureus 1199B, which overexpresses NorA. Boron-free analogues showed no biological activity, thus revealing that the boron atom is crucial for biological activity. This work describes the first reported efflux pump inhibitory activity of boronic acid derivatives.

INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, G1, n, A1, A2, A3, A4, Y1, Y2, and Y3 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.