176486-58-1

Basic information

• Product Name: [S-(R*,R*)]-2-[(N-Methoxy-N-methyl-amino)carbonyl]-4-[(triphenylmethyl)thio]-1-pyrrolidinecarboxylic acid, 1,1-dimethyl ethyl ester
• CAS NO: 176486-58-1
• Molecular Weight: 532.704
• Mol File: 176486-58-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [S-(R*,R*)]-2-[(N-Methoxy-N-methyl-amino)carbonyl]-4-[(triphenylmethyl)thio]-1-pyrrolidinecarboxylic acid, 1,1-dimethyl ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [S-(R*,R*)]-2-[(N-Methoxy-N-methyl-amino)carbonyl]-4-[(triphenylmethyl)thio]-1-pyrrolidinecarboxylic acid, 1,1-dimethyl ethyl ester(176486-58-1)
• EPA Substance Registry System: [S-(R*,R*)]-2-[(N-Methoxy-N-methyl-amino)carbonyl]-4-[(triphenylmethyl)thio]-1-pyrrolidinecarboxylic acid, 1,1-dimethyl ethyl ester(176486-58-1)

Safety Data

• Hazardous Substances Data: 176486-58-1(Hazardous Substances Data)

Upstream product

• 239064-77-8 O-mesyl-N-(tert-butoxycarbonyl)-hydroxyproline dimethylhydroxamide 
• 3695-77-0 triphenylmethanethiol 
• 143775-30-8 (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-N-methoxy-N-methylprolinamide 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 

Downstream Products

• 345915-09-5 isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate 
• 345915-10-8 isopropyl N-{5-({[(2S,4S)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate 

Relevant articles and documents

Application of an enantiomerically pure bicyclic thiolactone in the synthesis of a farnesyl transferase inhibitor

An efficient manufacturing route to a novel farnesyl transferase inhibitor is described. The target molecule is a pro-drug, and its synthesis is complicated by the presence of labile functionality. The Medicinal Chemistry synthesis required trityl mercapt