176707-77-0

Basic information

• Product Name: (R)-1-(3-Bromophenyl)ethylamine
• Synonyms: (R)-3-BROMO-ALPHA-METHYLBENZYLAMINE;(R)-(+)-3-BROMO A-METHYLBENZYLAMINE;(R)-1-(3-BROMOPHENYL)ETHANAMINE;(R)-1-(3-BROMOPHENYL)ETHYLAMINE;[(1R)-1-(3-Bromophenyl)ethyl]amine;(R)-1-(3-Bromophenyl)ethylamine, ChiPros 99%, ee 98+%;Benzenemethanamine, 3-bromo-α-methyl-, (αR)-;Albb-005066
• CAS NO: 176707-77-0
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: API intermediates
• Mol File: 176707-77-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 96°C/4mm
• Flash Point: 96°C/4mm
• Appearance: /
• Density: 1.33
• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive: Air Sensitive
• CAS DataBase Reference: (R)-1-(3-Bromophenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3-Bromophenyl)ethylamine(176707-77-0)
• EPA Substance Registry System: (R)-1-(3-Bromophenyl)ethylamine(176707-77-0)

Safety Data

• Hazard Codes: C,N
• Statements: 34-51/53-43-22
• Safety Statements: 26-36/37/39-61-45
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 176707-77-0(Hazardous Substances Data)

Usage

General Description

(R)-1-(3-Bromophenyl)ethylamine, also known as 3-Bromophenethylamine, is a chemical compound with the molecular formula C8H10BrN. It is a chiral amine with a molecular weight of 200.07 g/mol. (R)-1-(3-Bromophenyl)ethylamine is commonly used in organic and medicinal chemistry as a precursor for the synthesis of various pharmaceuticals and research chemicals. It is also used as an intermediate in the production of other organic compounds. Additionally, (R)-1-(3-Bromophenyl)ethylamine has potential applications in the development of new drugs and therapeutic agents due to its structural properties and reactivity. Overall, this compound plays a crucial role in the advancement of chemical and pharmaceutical research.

InChI:InChI=1/C8H10BrN/c1-6(10)7-3-2-4-8(9)5-7/h2-6H,10H2,1H3

Upstream product

• 687-47-8 (S)-Ethyl lactate 
• 74877-08-0 1-(3-bromophenyl)ethanamine 
• 623-50-7 ethyl 2-hydroxyacetate 
• 95-92-1 oxalic acid diethyl ester 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 108-22-5 Isopropenyl acetate 
• 185527-07-5 N-[1-(3-Bromo-phenyl)-ethyl]-oxalamic acid octyl ester 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 18523-22-3 2,3'-dibromoacetophenone 
• 1434602-84-2 (Z)-1-(3-bromophenyl)ethanone oxime 
• 1434603-05-0 (Z)-1-(3-bromophenyl) ethanone O-benzyloxime 
• 24280-05-5 N-[1-(3-bromophenyl)ethylidene]hydroxyl amine 
• 87227-77-8 bishydrochloride salt of cis-1,4-diamino-but-2-ene 
• 52780-14-0 1-(3-bromophenyl)ethanol 

Downstream Products

• 1187932-25-7 (R)-tert-butyl (1-(3-bromophenyl)ethyl)carbamate 
• 1381809-17-1 (E)-(2R,5S,11S,14S,17R,18R)-11-(3-hydroxy-benzyl)-14-isopropyl-18-methoxy-2,17-dimethyl-3,9,12,15,28-pentaaza-tricyclo[21.3.1.1*5,9*]octacosa-1⁽²⁷⁾,21,23,25-tetraene-4,10,13,16-tetraone 
• 1381813-33-7 [(R)-1-(3-vinyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 1381813-39-3 (R)-1-(3-vinylphenyl)ethylamine hydrochloride 
• 1381813-48-4 (S)-1-{(S)-3-[3-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-[(S)-2-((2R,3R)-3-methoxy-2-methyl-hept-6-enoylamino)-3-methyl-butyrylamino]-propionyl}-hexahydro-pyridazine-3-carboxylic acid [(R)-1-(3-vinyl-phenyl)-ethyl]-amide 
• 1381813-63-3 (E)-(2R,5S,11S,14S,17R,18R)-11-[3-(tert-butyl-dimethyl-silanyloxy)-benzyl]-14-isopropyl-18-methoxy-2,17-dimethyl-3,9,12,15,28-pentaaza-tricyclo[21.3.1.1*5,9*]octacosa-1⁽²⁷⁾,21,23,25-tetraene-4,10,13,16-tetraone 
• 1429293-30-0 (R)-N-(1-(3-bromophenyl)ethyl)-1-(2,4-difluorophenyl)-4-ethoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide 
• 1429187-89-2 (R)-benzyl 4-(3-(1-aminoethyl)phenyl)piperazine-1-carboxylate 
• 1429187-97-2 (R)-N-(1-(3-bromophenyl)ethyl)-3-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxamide 
• 1429217-23-1 (R)-N-(1-(3-bromophenyl)ethyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide 
• 1429187-90-5 (R)-benzyl 4-(3-(1-(tert-butoxycarbonylamino)ethyl)phenyl)piperazine-1-carboxylate 
• 1466528-30-2 (R)-tert-butyl 1-(3-(1H-pyrazol-4-yl)phenyl)ethylcarbamate 
• 1466528-31-3 (R)-tert-butyl 1-(3-(1-phenethyl-1H-pyrazol-4-yl)phenyl)ethylcarbamate 

Relevant articles and documents

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.

But-2-ene-1,4-diamine and But-2-ene-1,4-diol as Donors for Thermodynamically Favored Transaminase- and Alcohol Dehydrogenase-Catalyzed Processes

Both cis- and trans-but-2-ene-1,4-diamines have been prepared and efficiently applied as sacrificial cosubstrates in enzymatic transamination reactions. The best results were obtained with the cis-diamine. The thermodynamic equilibrium of the stereoselective transamination process is shifted to the amine formation due to tautomerization of 5H-pyrrole into 1H-pyrrole, achieving high conversions (78–99%) and enantiomeric excess (up to >99%) by using a small excess of the amine donor. Furthermore, when the reaction proceeded, a strong coloration was observed due to polymerization of 1H-pyrrole. A structurally related compound, cis-but-2-ene-1,4-diol, has been utilized as cosubstrate in different alcohol dehydrogenase (ADH)-mediated bioreductions. In this case, high conversions (91–99%) were observed due to a lactonization process. Both strategies are convenient from both synthetic and atom economy points of view in the production of valuable optically active products. (Figure presented.).

PROCESS FOR THE PREPARATION OF CHIRAL AMINES FROM PROCHIRAL KETONES

There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.