17689-17-7 Usage
Description
5-CARBOXY-1-PENTANETHIOL, also known as 6-Mercaptohexanoic acid (MHA), is a colorless to yellow liquid that forms a self-assembled monolayer (SAM) used to cap a variety of materials such as gold nanoparticles (AuNPs) and indium phosphide quantum dots (InPQDs). It is primarily used for immobilizing surface molecules, which enhances the physio-chemical and electrical properties of the materials.
Uses
Used in Surface Modification:
5-CARBOXY-1-PENTANETHIOL is used as a surface modifier for materials like InP quantum nanowires and gold nanoparticles. It helps in immobilizing the surface molecules, which in turn enhances the physio-chemical and electrical properties of these materials.
Used in Fluorescent Chemical Sensors:
5-CARBOXY-1-PENTANETHIOL is used as a component in the development of fluorescent chemical sensors that monitor cyanide ions. Its surface modification properties make it suitable for this application.
Used in Biosensor Applications:
In the field of biosensors, 5-CARBOXY-1-PENTANETHIOL is used for covalently bonding with liposomes to form a SAM on the surface of gold. This application is particularly useful for insect odorant receptor-based biosensors.
Used in Pharmaceutical and Chemical Industries:
5-CARBOXY-1-PENTANETHIOL is used as a building block or intermediate in the synthesis of various pharmaceutical and chemical compounds due to its unique thiol and carboxylic acid functional groups.
Used in Material Science:
In material science, 5-CARBOXY-1-PENTANETHIOL is used as a capping agent for quantum dots and nanoparticles, which helps in controlling their size, shape, and stability. This application is crucial for the development of advanced materials with tailored properties.
Check Digit Verification of cas no
The CAS Registry Mumber 17689-17-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,8 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17689-17:
(7*1)+(6*7)+(5*6)+(4*8)+(3*9)+(2*1)+(1*7)=147
147 % 10 = 7
So 17689-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H12O2S/c7-6(8)4-2-1-3-5-9/h9H,1-5H2,(H,7,8)
17689-17-7Relevant articles and documents
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Overberger,C.G.,Weise,J.K.
, p. 3533 - 3537 (1968)
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Redox responsive paclitaxel dimer for programmed drug release and selectively killing cancer cells
Hu, Xiuli,Pei, Qing,Wang, Jian,Wang, Zhanfeng,Xia, Rui,Xie, Zhigang
, p. 785 - 793 (2020/07/30)
Redox stimulus responsive drug delivery systems have been widely investigated and proved to be promising prospects for efficient cancer therapy due to the abnormal high level of reactive oxygen species and glutathione in tumor microenvironment. Herein, three paclitaxel dimers (named as PTX2-R, R = S, Se and Te) bridged with alkyl sulfide, selenide or telluride are synthesized. These dimers can self-assemble into stable uniform nanoparticles (named as PTX2-R NPs, R = S, Se and Te) with impressively high drug loading. As expected, sulfur/selenium/tellurium bonds exhibit different redox responsiveness, thereby affecting the drug release and cytotoxicity. Of note, tellurium bridged paclitaxel dimer shows ultra-sensitivity to hydrogen peroxide, which rapidly cleaves into two paclitaxel under the subsequent dithiothreitol stimulation. Our findings provide deep insight into the redox sensitivity of chalcogenide elements and offer the rational design strategies to biologically redox condition for programmed drug release.
CNP PRODRUGS WITH CARRIER ATTACHMENT AT THE RING MOIETY
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Page/Page column 214; 215, (2017/08/01)
The present invention relates to CNP prodrugs in which the carrier is covalently and reversibly attached to the ring moiety of a CNP moiety, to pharmaceutical compositions comprising such CNP prodrugs, to their uses and to methods of treating diseases that can be treated with the CNP prodrugs of the present invention.
