176962-15-5Relevant articles and documents
Benzyne addition to N-alkyl-4-hydroxy-1-methylisoquinolinium salts; a new and convenient synthesis of (±)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5,10-imine (MK801)
Constable, Kevin P.,Blough, Bruce E.,Carroll, F. Ivy
, p. 717 - 718 (1996)
Addition of benzyne, generated by three different methods, to N-benzyl-4-hydroxy-1-methylisoquinolinium betaine provides N-benzyl-5-methyl-11-oxo-5H-dibenzo[a,d] cyclohepten-5,10-imine which can be converted to MK801.