1773-49-5Relevant articles and documents
2,4-Dinitrophenyl hydrazone derivatives as potent alpha amylase inhibitors
Adil, M.,Ahmad, Shakeel,Faisal, Shah,Haq, Mirajul,Hassan, Amir,Idrees, M.,Kainat,Yousaf, Muhammad,Zia, Huma
, p. 277 - 282 (2021/09/28)
In our current study thirteen new 2,4-dinitrophenyl hydrazone derivatives 1-13 have been evaluated for alpha amylase activity. The molecular docking results indicate that compounds potentially bind in the catalytic site of the enzyme with excellent result. Molecular Operating Environment (MOE) software was used for docking study. 2,4-Dinitrophenyl hydrazone 1-13 have been obtained under reflux conditions by reacting dinitrophenyl hydrazine in methanol with different aromatic as well as aliphatic aldehydes in the presence of acetic acid act as a catalyst. The current results have shown that compounds 5 (IC50 =12.16μg/mL), 6 (IC50 =15.03μg/mL), and 12 (IC50 =16.42 μg/mL) have been found to be the more potent alpha amylase inhibitors as compared to the standard acarbose (IC50 = 42.47μg/mL). These compounds may provide better leads for alpha amylase inhibitor and further assessment of these compounds can be of great help in the discovery of new antidiabetic drugs.
Correlation analysis of reactivity in the oxidation of substituted benzyl alcohols by benzimidazolium dichromate - A kinetic and mechanistic aspects
Kumar, Pravesh,Panday, Dinesh,Kothari, Seema
, p. 1207 - 1215 (2020/06/27)
The oxidation of a number of para- and meta-substituted benzyl alcohols by benzimidazolium dichromate (BIDC), in dimethyl sulphoxide, leads to the formation of the corresponding benzaldehydes. The reaction is first order with respect to each BIDC and alcohol. The reaction is catalyzed by hydrogen ions and the dependence has the form kobs = a + b[H+]. The oxidation of [1,1-2H2]benzyl alcohol exhibited the presence of a substantial kinetic isotope effect. The rates of the oxidation of meta-substituted benzyl alcohols correlated best with Taft's σ1 and σR0 constants. The para-substituted compounds exhibited excellent correlation with σ1 and σRBA values. The polar reaction constants are negative. The rate of oxidation of benzyl alcohol was determined in nineteen organic solvents. An analysis of the solvent effect by multiparametric equations indicated the greater importance of the cation-solvating power of the solvents. Suitable mechanisms have been discussed.
Synthesis, characterization and biological evaluation of substituted novel pyrazolone and pyrazole derivatives
Sabale, Prafulla M.,Patel, Ronak S.
, p. 143 - 148 (2019/01/21)
In the present investigation, series of 2-(4-methoxybenzyl) substituted-3-methyl- 1,2-dihydropyrazol-5-one and 2-(4-methoxybenzyl)-substituted-3,5-dimethyl-2,5-dihydro- 1H-pyrazole have been synthesized. All synthesized compounds were characterized and te
