177404-21-6

Basic information

• Product Name: LEPTIN, HUMAN
• Synonyms: LEPTIN;LEPTIN, HUMAN;LEPTIN (HUMAN) (RECOMBINANT);HUMAN OB;HUMAN OBESITY PROTEIN;HUMAN LEPTIN;RHOB;RECOMBINANT HUMAN LEPTIN
• CAS NO: 177404-21-6
• Molecular Weight: 0
• Product Categories: monoclonal antibody;Cytokine
• Mol File: 177404-21-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: LEPTIN, HUMAN(CAS DataBase Reference)
• NIST Chemistry Reference: LEPTIN, HUMAN(177404-21-6)
• EPA Substance Registry System: LEPTIN, HUMAN(177404-21-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 177404-21-6(Hazardous Substances Data)

Usage

Description

Leptin, also known as LEPTIN, HUMAN, is an adipocyte hormone secreted from white adipose tissues that plays a crucial role in regulating energy expenditure and food intake by acting on receptors located in the hypothalamus.

Uses

Used in Pharmaceutical Industry:
LEPTIN, HUMAN is used as a therapeutic agent for the treatment of lipodystrophy in clinical settings. Leptin analogs help in managing this rare disorder characterized by the absence of body fat, which can lead to severe metabolic complications.
Used in Research Applications:
LEPTIN, HUMAN serves as an important research tool for studying the mechanisms of body weight regulation, energy homeostasis, and the central nervous system's role in appetite control. Understanding the functions of leptin can contribute to the development of novel treatments for obesity and related metabolic disorders.

Structure

Leptin is produced as a 167-aa residue preprohormone, including an N-terminal 21-aa signal peptide, and is released as a 146-aa peptide after enzymatic cleavage.

Properties

Human leptin: Mr 16,000, pI 5.8. Leptin is soluble in water.

Gene, mRNA, and precursor

The human leptin gene, LEP, location 7q31.3, consists of three exons. Human leptin mRNA has a 3.5kb length that encodes a signal peptide of 21 aa residues and a mature protein of 146 aa residues.

Regulation of synthesis and release

The synthesis and release of leptin are regulated by environmental factors. In humans and rodents, obesity stimulates leptin synthesis and increases the plasma concentrations. Exercise decreases the plasma leptin concentrations in the rat. Exposure to low temperature suppresses leptin gene expression in WAT and reduces the plasma leptin concentrations in rodents. While fasting attenuates leptin gene expression, feeding restores the levels of gene expression.