177736-15-1Relevant articles and documents
MOF-derived cobalt nanoparticles catalyze a general synthesis of amines
Jagadeesh, Rajenahally V.,Murugesan, Kathiravan,Alshammari, Ahmad S.,Neumann, Helfried,Pohl, Marga-Martina,Radnik, J?rg,Beller, Matthias
, p. 326 - 332 (2017/09/28)
The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chemical research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobaltdiamine- dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atmosphere.The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples).The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and molecular hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.
Ruthenium N-heterocyclic carbene catalysts for selective reduction of nitriles to primary amines
Addis, Daniele,Enthaler, Stephan,Junge, Kathrin,Wendt, Bianca,Beller, Matthias
experimental part, p. 3654 - 3656 (2009/10/04)
Easily accessible in situ catalysts composed of [Ru(cod)(2-methylallyl)2] and N-heterocyclic carbene ligands have been developed for the environmentally benign hydrogenation of various nitriles to give primary amines. Applying optimized conditions in the presence of SIMesBF4 as ligand high catalyst activity of up to 392 h-1 is achieved in the hydrogenation of benzonitrile. The general applicability and functional group tolerance of this novel catalyst system are shown in the reduction of ten different nitriles.
The discovery and preparation of disubstituted novel amino-aryl-piperidine- based renin inhibitors
Cody, Wayne L.,Holsworth, Daniel D.,Powell, Noel A.,Jalaie, Mehran,Zhang, Erli,Wang, Wei,Samas, Brian,Bryant, John,Ostroski, Robert,Ryan, Michael J.,Edmunds, Jeremy J.
, p. 59 - 68 (2007/10/03)
Recently, trans-disubstituted oxo-aryl-piperidines have been identified as small molecule nonpeptide renin inhibitors for the modulation of hypertension. Herein, we report on the discovery and preparation of a new class of novel cis-disubstituted amino-aryl-piperidines as a mixture of enantiomers that are potent in vitro renin inhibitors and also, possess in vivo antihypertensive activity in a double transgenic mouse model.
