177966-60-8

Basic information

• Product Name: FMOC-L-3-BENZOTHIENYLALANINE
• Synonyms: Fmoc-Beta-(3-Benzothien;3-(3-Benzothienyl)-N-FMoc-L-alanine, 95%;FMoc-b-(3-benzothienyl)-Ala-OH;Fmoc-3-L-Ala(3-benzothienyl)-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-3-(3-BENZOTHIENYL)-L-ALANINE;N-ALPHA-FMOC-BETA-(3-BENZOTHIENYL)-L-ALANINE;RARECHEM BK PT 0205;FMOC-3-(3-BENZOTHIENYL)-L-ALANINE
• CAS NO: 177966-60-8
• Molecular Formula: C26H21NO4S
• Molecular Weight: 443.51
• Product Categories: Amino Acids;Phenylalanine analogs and other aromatic alpha amino acids;Amino Acid Derivatives;a-amino
• Mol File: 177966-60-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 690.848 °C at 760 mmHg
• Flash Point: 371.612 °C
• Appearance: /
• Density: 1.356 g/cm³
• Vapor Pressure: 4.88E-20mmHg at 25°C
• Refractive Index: 1.687
• Storage Temp.: 2-8°C
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: FMOC-L-3-BENZOTHIENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-3-BENZOTHIENYLALANINE(177966-60-8)
• EPA Substance Registry System: FMOC-L-3-BENZOTHIENYLALANINE(177966-60-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 177966-60-8(Hazardous Substances Data)

Usage

Description

FMOC-L-3-BENZOTHIENYLALANINE is a synthetic amino acid derivative that features a benzothiophene moiety attached to the alpha-carbon of the L-alanine molecule. The Fmoc (9-fluorenylmethoxycarbonyl) group is a protecting group for the alpha-amino group, which is commonly used in peptide synthesis. FMOC-L-3-BENZOTHIENYLALANINE is characterized by its white to off-white powder appearance and is known for its high degree of flexibility when incorporated into a polypeptide chain.

Uses

Used in Proteomics Studies:
FMOC-L-3-BENZOTHIENYLALANINE is used as a building block for the synthesis of novel peptides and proteins in proteomics research. The unique benzothiophene side chain provides distinct chemical and biological properties, allowing for the exploration of new protein functions and interactions.
Used in Solid Phase Peptide Synthesis (SPPS):
In the field of solid phase peptide synthesis, FMOC-L-3-BENZOTHIENYLALANINE is used as a non-natural amino acid for the construction of peptides with specific properties. The Fmoc group facilitates orthogonal deprotection strategies, enabling the stepwise assembly of peptide chains with high efficiency and selectivity.
Used in Pharmaceutical Industry:
FMOC-L-3-BENZOTHIENYLALANINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. The benzothiophene moiety can impart unique biological activities, making it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
As a synthetic amino acid derivative, FMOC-L-3-BENZOTHIENYLALANINE is used in chemical research to study the effects of non-natural amino acids on protein structure, function, and stability. This knowledge can be applied to the design of new bioactive molecules and the understanding of protein folding and interactions.

InChI:InChI=1/C26H21NO4S/c28-25(29)23(13-16-15-32-24-12-6-5-7-17(16)24)27-26(30)31-14-22-20-10-3-1-8-18(20)19-9-2-4-11-21(19)22/h1-12,15,22-23H,13-14H2,(H,27,30)(H,28,29)/t23-/m0/s1

Downstream Products

• 1213772-90-7 O-W-Bal-I-F-H(1-Bzl)-NH₂ 
• 1213773-54-6 O-W-F-I-Bal-H(1-Bzl)-NH₂