178375-24-1

Basic information

• Product Name: 1-(3-methyl-4-triisopropylsilyloxyphenyl)-2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one
• Synonyms: 1-(3-methyl-4-triisopropylsilyloxyphenyl)-2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one
• CAS NO: 178375-24-1
• Molecular Weight: 513.768
• Mol File: 178375-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-methyl-4-triisopropylsilyloxyphenyl)-2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-methyl-4-triisopropylsilyloxyphenyl)-2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one(178375-24-1)
• EPA Substance Registry System: 1-(3-methyl-4-triisopropylsilyloxyphenyl)-2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-propan-1-one(178375-24-1)

Safety Data

• Hazardous Substances Data: 178375-24-1(Hazardous Substances Data)

Upstream product

• 178374-81-7 3-methyl-4-triisopropylsilyloxy-α-bromopropiophenone 
• 3888-65-1 4-(4-fluorophenyl)piperidin-4-ol 

Relevant articles and documents

Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone-A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain

(-)-6-[2-[4-(3-Fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone was identified as an orally active NR2B-subunit selective N-methyl-d-aspartate (NMDA) receptor antagonist. It has very high selectivity for NR2B subunits c