178603-78-6 Usage
Description
AC-YVAD-CMK, also known as Caspase-1 inhibitor II, is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. It is a selective inhibitor of interleukin-1β converting enzyme (ICE), a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. AC-YVAD-CMK possesses neuroprotective properties in a rat model of cerebral ischemia and can inhibit Fas-mediated apoptosis and acidic sphingomyelinase activation at higher concentrations.
Uses
Used in Neuroscience Research:
AC-YVAD-CMK is used as a neuroprotective agent in a rat model of cerebral ischemia, providing insights into the role of Caspase-1 in neurodegenerative diseases and potential therapeutic targets.
Used in Immunology Research:
AC-YVAD-CMK is used as an inflammasome inhibitor to add to THP-1 cells or peripheral blood mononuclear cells (PBMC) before stimulation, helping researchers understand the role of inflammasomes in immune responses.
Used in In Vivo Models:
AC-YVAD-CMK is used as a caspase-1 inhibitor in C57BL/6 mice, injected to evaluate its effects on various biological processes and its potential as a therapeutic agent.
Used in Hematopoietic Stem Cell Transplantation (HSCT) Research:
AC-YVAD-CMK is used as a caspase-1 inhibitor, administered into mice before and during HSCT, to evaluate its effect on bone marrow inflammatory injury and its potential to improve transplantation outcomes.
Used in Vascular Biology Research:
AC-YVAD-CMK is used to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER), providing insights into the role of Caspase-1 in vascular function and disease.
Used in Oncology Research:
AC-YVAD-CMK is used as a caspase 1 inhibitor to treat MCF-7 tumor xenograft mice, helping to validate the role of inflammasomes activation in tumor growth and explore potential therapeutic strategies for cancer treatment.
Biochem/physiol Actions
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.
Check Digit Verification of cas no
The CAS Registry Mumber 178603-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,6,0 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 178603-78:
(8*1)+(7*7)+(6*8)+(5*6)+(4*0)+(3*3)+(2*7)+(1*8)=166
166 % 10 = 6
So 178603-78-6 is a valid CAS Registry Number.
