178698-88-9

Basic information

• Product Name: 4-amino-2-ethylphenol
• Synonyms: 4-amino-2-ethylphenol
• CAS NO: 178698-88-9
• Molecular Weight: 137.181
• Mol File: 178698-88-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-amino-2-ethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-2-ethylphenol(178698-88-9)
• EPA Substance Registry System: 4-amino-2-ethylphenol(178698-88-9)

Safety Data

• Hazardous Substances Data: 178698-88-9(Hazardous Substances Data)

Upstream product

• 191602-86-5 1-(benzyloxy)-2-bromo-4-nitrobenzene 
• 5847-59-6 2-bromo-4-nitrophenol 
• 15516-56-0 2-Ethyl-p-nitroso-phenol 
• 90-00-6 o-Hydroxyethylbenzene 
• 100-12-9 4-ethylnitrobenzene 
• 144-62-7 oxalic acid 
• 7664-93-9 sulfuric acid 
• 107244-56-4 2-ethyl-4-(hydroxyimino)cyclohexa-2,5-dienone 

Downstream Products

• 1207950-11-5 diethyl (4-hydroxy-3-ethylphenyl)aminomethylenemalonate 
• 912949-19-0 tert-butyl 3-ethyl-4-hydroxyphenylcarbamate 
• 1574541-48-2 4-(tert-butyldimethylsilyloxy)-3-ethylaniline 
• 1574538-25-2 3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574538-26-3 3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574538-24-1 (±)-3-(biphenyl-4-yloxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574541-71-1 3-bromo-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574541-70-0 3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)aniline 
• 1574541-69-7 tert-butyl 3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenylcarbamate 
• 1574538-16-1 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574538-15-0 (S)-3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)pyrrolidin-2-one 
• 1574541-53-9 (R)-2-(4-(3-(4-cyclopropylphenoxy)-2-oxopyrrolidin-1-yl)-2-ethylphenoxy)ethyl methanesulfonate 
• 1574541-52-8 (S)-2-(4-(3-(4-cyclopropylphenoxy)-2-oxopyrrolidin-1-yl)-2-ethylphenoxy)ethyl methanesulfonate 
• 1574543-06-8 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(2-hydroxyethoxy)phenyl)pyrrolidin-2-one 

Relevant articles and documents

SUBSTITUTED 3-((3-AMINOPHENYL)AMINO)PIPERIDINE-2,6-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are piperidine dione compounds having the following structure (I) wherein RN, R1, R2, R3, R4, L,V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists

3-(tert-Butyl)-4-hydroxyphenyl 2,4-dichlorobenzoate (1) was discovered in our in-house high throughput screening as a moderate FXR antagonist. To improve the potency and the stability of the hit 1, forty derivatives were synthesized and SAR was systematically explored. The results turn out that replacing the 2,4-dichlorophenyl with 2,6-dichloro-4-amidophenyl shows great improvement in potency, replacing the benzoate with benzamide shows improvement in stability and slight declining of potency and 3-(tert-butyl)-4-hydroxyphenyl unit is essential in obtaining the FXR antagonistic activity.

Synthesis and anticoccidial activities of eight novel ethyl 7-alkyl-6-(2-aryloxyethoxy)-4-hydroxyquinoline-3-carboxylates

Eight novel ethyl 7-alkyl-6-(2-aryloxyethoxy)-4-hydroxyquinoline-3- carboxylates were synthesised and their structures were identifi ed by 1H NMR, MS, and IR spectra. The anticoccidial activities of these compounds were evaluated according to the ACI (the anticoccidial index) method. The results showed that two of these compounds exhibited anticoccidial activities against Eimeria tenella in the chicken' diet with a dose of 27 mg kg-1.