1787-44-6 Usage
Description
METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE, with the chemical formula C19H20BrD3P and CAS# 1787-44-6, is an isotopically labeled research compound. It is a derivative of triphenylphosphonium bromide, where the methyl group is deuterated (D3), which means it contains three deuterium atoms instead of hydrogen atoms. METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE is primarily used in scientific research and development, particularly in the field of chemistry and biochemistry.
Uses
Used in Chemical Research:
METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE is used as a research compound for studying the properties and reactions of isotopically labeled molecules. The incorporation of deuterium atoms allows researchers to investigate the effects of isotopic substitution on chemical reactivity, reaction kinetics, and the stability of the compound.
Used in Biochemical Studies:
In the field of biochemistry, METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE is used as a labeled compound to trace metabolic pathways and enzyme mechanisms. The deuterium labeling provides a means to differentiate between the labeled and unlabeled molecules, enabling researchers to monitor the progress of biochemical reactions and understand the underlying processes.
Used in Pharmaceutical Development:
METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE is employed as a tool in the development of new pharmaceuticals. The isotopically labeled compound can be used to study drug metabolism, pharmacokinetics, and pharmacodynamics, providing valuable insights into the behavior of drug candidates and their potential therapeutic applications.
Used in Environmental Studies:
In environmental science, METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE can be utilized to investigate the fate and transport of chemicals in the environment. The deuterium labeling allows for the tracking of the compound's movement and transformation, helping to assess the environmental impact and potential risks associated with the release of such chemicals.
Used in Analytical Chemistry:
METHYL-D3-TRIPHENYLPHOSPHONIUM BROMIDE is used as an internal standard or a reference compound in analytical chemistry. The isotopically labeled nature of the compound provides a stable and reliable reference point for the quantification and identification of other compounds in complex mixtures, improving the accuracy and precision of analytical measurements.
Check Digit Verification of cas no
The CAS Registry Mumber 1787-44-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,8 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1787-44:
(6*1)+(5*7)+(4*8)+(3*7)+(2*4)+(1*4)=106
106 % 10 = 6
So 1787-44-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1/i1D3;
1787-44-6Relevant articles and documents
Nickel(0)-Catalyzed Asymmetric Ring Expansion Toward Enantioenriched Silicon-Stereogenic Benzosiloles
Ju, Cheng-Wei,Yan, Nuo,Zhang, Jinyu,Zhao, Dongbing
supporting information, p. 25723 - 25728 (2021/11/09)
The development of a straightforward strategy to obtain enantioenriched silicon-stereogenic benzosiloles remains a challenging yet appealing synthesis venture due to their potential future application in chiral electronic and optoelectronic devices. In this context, all of the existing methods rely on Rh-catalyzed systems and are somewhat limited in scope. Herein, we disclose the first Ni0-catalyzed ring expansion process that enables the preparation of benzosiloles possessing tetraorganosilicon stereocenters in excellent yields and enantioselectivities. The presented catalysis strategy is further applied to the asymmetric synthesis of silicon-stereogenic bis-silicon-bridged π-extended systems. Preliminary studies reveal that such compounds exhibit fluorescence emission, Cotton effects and circularly polarized luminescence (CPL) activity.
Ni-Catalyzed Cyclization of Enynes and Alkynylboronates: Atom-Economical Synthesis of Boryl-1,4-dienes
Cabrera-Lobera, Natalia,Quirós, M. Teresa,Bu?uel, Elena,Cárdenas, Diego J.
supporting information, p. 14512 - 14516 (2019/11/11)
We report a novel atom-economical Ni-catalyzed cyclization reaction of enynes with alkynylboronates. The reaction employs a non-expensive Ni salt, a phosphine-based ligand and easy-handling alkynylboronates as boron–carbon source. The reaction provides co
Chlorination of phenylallene derivatives with 1-chloro-1,2-benziodoxol-3-one: Synthesis of vicinal-dichlorides and chlorodienes
Zhao, Zhensheng,Murphy, Graham K.
supporting information, p. 796 - 802 (2018/04/16)
Allyl and vinyl chlorides represent important structural motifs in organic chemistry. Herein is described the chemoselective and regioselective reaction of aryl- and α-substituted phenylallenes with the hypervalent iodine (HVI) reagent 1-chloro-1,2-benz-iodoxol-3-one. The reaction typically results in vicinal dichlorides, except with proton-containing α-alkyl substituents, which instead give chlorinated dienes as the major product. Experimental evidence suggests that a radical mechanism is involved.
