17880-88-5 Usage
General Description
2,3-Dichloroquinoxaline-6-carbonyl chloride is a chemical compound with the molecular formula C8H3Cl3N2O2. It is a derivative of quinoxaline and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2,3-DICHLORO QUINOXALINE-6-CARBONYL CHLORIDE is highly reactive and can easily undergo chemical reactions to form other compounds. It is a white to pale yellow solid at room temperature and is typically handled and used in a controlled laboratory environment due to its hazardous nature. 2,3-Dichloroquinoxaline-6-carbonyl chloride is an important building block in organic synthesis and is widely utilized in the manufacturing of various compounds for medical and agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 17880-88-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,8,8 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17880-88:
(7*1)+(6*7)+(5*8)+(4*8)+(3*0)+(2*8)+(1*8)=145
145 % 10 = 5
So 17880-88-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H4Cl2N2O2/c10-7-8(11)13-6-3-4(9(14)15)1-2-5(6)12-7/h1-3H,(H,14,15)
17880-88-5Relevant articles and documents
Bioorthogonal Ligation and Cleavage by Reactions of Chloroquinoxalines with ortho-Dithiophenols
Fu, Hua,Li, Hongyun,Li, Youshan,Lou, Zhenbang,Yang, Haijun,Zhao, Yufen
, p. 3671 - 3677 (2020)
A bioorthogonal ligation and cleavage method via reactions of chloroquinoxalines (CQ) and ortho-dithiophenols (DT) is presented. Double nucleophilic substitutions of ortho-dithiophenols to chloroquinoxalines provide conjugates containing tetracyclic benzo[5,6][1,4]dithiino[2,3-b]quinoxaline with strong built-in fluorescence together with release of the other functional molecules. Three cleavable linkers were designed and successfully used in release of the molecules containing biotin from the protein conjugates. The CQ-DT bioorthogonal reactions can be applied for the bioorthogonal ligations, bioorthogonal cleavages, and trans-tagging of proteins, and show advantages of readily accessible unnatural orthogonal groups, appealing reaction kinetics (k2≈1.3 m?1 s?1), excellent biocompatibility of orthogonal groups, and high stability of conjugates. This complements previous bioorthogonal reactions and is a new route for protein-fishing applications and in-gel fluorescence analysis.
