179324-21-1 Usage
Description
Z-Leu-Leu-BoroLeu-Pinanediol (MG261) is a synthetic chemical compound that features a boronic acid functionality. It is recognized for its potent and selective inhibition of the proteasome, a critical cellular protein degradation mechanism that governs numerous cellular processes. MG261 is extensively utilized as a research tool to investigate the function of the proteasome and its implications in various diseases. Z-Leu-Leu-BoroLeu-Pinanediol (MG261)'s boronic acid component enables it to target and bind specifically to the proteasome's catalytic site, thereby inhibiting its activity. This leads to the accumulation of ubiquitinated proteins and, ultimately, to cell death. MG261 has demonstrated its potential as a therapeutic agent for treating cancer and other conditions marked by abnormal proteasome activity.
Uses
Used in Pharmaceutical Research:
Z-Leu-Leu-BoroLeu-Pinanediol (MG261) is used as a research tool for studying the function of the proteasome and its role in diseases. Its ability to inhibit the proteasome makes it valuable in understanding the cellular processes regulated by this protein degradation machinery.
Used in Cancer Therapy:
In the field of oncology, Z-Leu-Leu-BoroLeu-Pinanediol (MG261) is used as a potential therapeutic agent for the treatment of cancer. Its mechanism of action involves the inhibition of the proteasome, leading to the accumulation of ubiquitinated proteins and inducing cell death, which can be particularly effective against cancer cells with dysregulated proteasome activity.
Used in Drug Development:
MG261 is also utilized in the development of drugs targeting the proteasome. Its selectivity and potency make it a promising candidate for the creation of new therapeutics aimed at treating diseases associated with the malfunctioning of the proteasome.
Used in Biochemical Studies:
In the biochemical research industry, Z-Leu-Leu-BoroLeu-Pinanediol (MG261) is used as a specific inhibitor to study the effects of proteasome inhibition on cellular processes. This helps researchers to dissect the complex pathways and mechanisms influenced by the proteasome, contributing to a deeper understanding of cellular biology and disease mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 179324-21-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,3,2 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 179324-21:
(8*1)+(7*7)+(6*9)+(5*3)+(4*2)+(3*4)+(2*2)+(1*1)=151
151 % 10 = 1
So 179324-21-1 is a valid CAS Registry Number.
