17933-83-4Relevant articles and documents
Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation
Wakaki, Takayuki,Togo, Takaya,Yoshidome, Daisuke,Kuninobu, Yoichiro,Kanai, Motomu
, p. 3123 - 3128 (2018/04/14)
We developed a palladium-catalyzed C-H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C-H bond activation pathway.
Proton-abstraction mechanism in the palladium-catalyzed intramolecular arylation: Substituent effects
Garcia-Cuadrado, Domingo,De Mendoza, Paula,Braga, Ataualpa A. C.,Maseras, Feliu,Echavarren, Antonio M.
, p. 6880 - 6886 (2008/02/05)
The regioselectivity observed in the intramolecular palladium-catalyzed arylation of substituted bromobenzyldiarylmethanes as well as theoretical results demonstrate that the Pd-catalyzed arylation proceeds by a mechanism involving a proton abstraction by