179388-65-9 Usage
Description
AH 11110 HYDROCHLORIDE is an α1B-adrenoceptor selective drug that exhibits interactions with both α1-adrenoceptors and α2-adrenoceptors. It is a pharmaceutical compound with potential applications in various medical fields due to its receptor selectivity and interaction properties.
Uses
Used in Pharmaceutical Industry:
AH 11110 HYDROCHLORIDE is used as a selective drug for targeting α1B-adrenoceptors, which play a crucial role in various physiological processes and conditions. Its interaction with α1-adrenoceptors and α2-adrenoceptors makes it a potential candidate for the development of novel therapeutic strategies in the treatment of conditions related to these receptors.
Used in Research and Development:
AH 11110 HYDROCHLORIDE is used as a research tool for studying the function and role of α1B-adrenoceptors in cellular and molecular processes. Its selective interaction with these receptors can help researchers gain a better understanding of their involvement in various diseases and disorders, leading to the development of more targeted and effective treatments.
Used in Drug Discovery and Design:
AH 11110 HYDROCHLORIDE serves as a starting point for the design and development of new drugs with improved selectivity and efficacy. By understanding its interaction with α1-adrenoceptors and α2-adrenoceptors, researchers can design drugs that specifically target these receptors, potentially leading to more effective treatments with fewer side effects.
Biological Activity
A subtype-selective ligand for the α 1B -adrenoceptor. The pK i values for binding to rat fibroblast cell membranes expressing α 1B (hamster), α 1A (bovine) and α 1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α 1 subtypes and α 2 receptors in smooth muscle preparations.
references
[1]. erami c, zhang h, ho jg, et al. alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. am j physiol heart circ physiol, 2002, 283(4): h1577-1587.[2]. eltze m, k?nig h, ullrich b, et al. failure of ah11110a to functionally discriminate between alpha(1)-adrenoceptor subtypes a, b and d or between alpha(1)- and alpha(2)-adrenoceptors. eur j pharmacol, 2001, 415(2-3): 265-276.
Check Digit Verification of cas no
The CAS Registry Mumber 179388-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,3,8 and 8 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 179388-65:
(8*1)+(7*7)+(6*9)+(5*3)+(4*8)+(3*8)+(2*6)+(1*5)=199
199 % 10 = 9
So 179388-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H26N2O2.ClH/c22-21(23-13-7-2-8-14-23)15-18(24)16-25-20-12-6-5-11-19(20)17-9-3-1-4-10-17;/h1,3-6,9-12,18,22,24H,2,7-8,13-16H2;1H
