179417-69-7

Basic information

• Product Name: TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID
• Synonyms: TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID;Boc-DL-(2-methoxyphenyl)glycine;a-(Boc-amino)-2-methoxybenzeneacetic acid;Boc-RS-2-methoxyphenylglycine
• CAS NO: 179417-69-7
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.3
• Mol File: 179417-69-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 451.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.189±0.06 g/cm3(Predicted)
• PKA: 3.35±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID(179417-69-7)
• EPA Substance Registry System: TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID(179417-69-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 179417-69-7(Hazardous Substances Data)

Usage

General Description

TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID is a chemical compound with the molecular formula C14H19NO5. It is a white to off-white crystalline powder that is used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical compounds. TERT-BUTOXYCARBONYLAMINO-(2-METHOXY-PHENYL)-ACETIC ACID is a derivative of acetic acid, and the presence of the t-Boc protecting group makes it useful for controlling reactions in organic synthesis. Its specific properties and potential applications in drug development make it a valuable compound for research and development in the pharmaceutical industry.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 271583-17-6 2-amino-2-(2-methoxyphenyl)acetic acid 
• 124-38-9 carbon dioxide 
• 1291065-82-1 C₂₅H₄₅NO₃Sn 

Downstream Products

• 1111734-24-7 [{(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-carbamoyl}-(2-methoxyphenyl)-methyl]-carbamic acid tert-butyl ester 
• 1111731-80-6 ({(3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-carbamoyl}-phenyl-methyl)-carbamic acid tert-butyl ester 
• 1201195-03-0 (R,S)-2-Amino-2-(2-methoxy-phenyl)-N-(6-methoxy-pyridin-3-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide 
• 1352721-81-3 methyl 2-(N-tert-butoxycarbonylamino)-2-(2-methoxylphenyl)acetate 

Relevant articles and documents

Synthesis ofN-Boc-α-amino Acids from Carbon Dioxide by Electrochemical Carboxylation ofN-Boc-α-aminosulfones

Electrochemical reduction ofN-Boc-α-aminosulfones in DMF using an undivided cell equipped with a Pt plate cathode and an Mg rod anode under atmospheric pressure of bubbling carbon dioxide through the solution under constant current conditions resulted in a reductive C-S bond cleavage with elimination of benzenesulfinate ion generating the corresponding anion species followed by fixation of carbon dioxide to give the correspondingN-Boc-α-amino acids in moderate to good yields.

HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to novel compounds of formula (I) which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

NOVEL COMPOUNDS

Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.