17949-65-4 Usage
Description
Zinc picolinate is an organic zinc supplement wherein the zinc atom is attached to a picolinic acid molecule. It is a white powder that is slightly soluble in water. Studies have suggested that zinc supplements, including zinc picolinate, may reduce the incidence of respiratory infections in children. Zinc picolinate is a highly available form of zinc supplement, easily dissolved to release the elemental zinc for use in the body. However, there are very few scientific studies to back the claim of its greater bioavailability compared to other zinc supplements.
Uses
Used in Pharmaceutical Industry:
Zinc picolinate is used as a therapeutic agent for various health conditions due to its pharmacological activity. It has been shown to reduce tumor growth and tumor diameter in oviduct of Coturnix japonica, indicating its potential use in cancer treatment.
Used in Dermatology:
Zinc picolinate is used as a therapeutic agent against acne vulgaris, stasis ulcers, and acrodermatitis enteropathica. Its absorbable zinc content makes it a valuable source for treating these skin conditions.
Used in Nutritional Supplements:
Zinc picolinate is used as a zinc supplement in various forms, such as tablets, capsules, and powders. It is easily dissolved and releases elemental zinc for use in the body, making it a popular choice for those seeking to improve their zinc intake and overall health.
Preparation
synthesis of zinc picolinate: Thirty grams of ZnSO4.7H2O was dissolved in 200 ml. deionized water at room temperature. Thereafter, 20 g. picolinic acid (Sigma Chemical, St. Louis, MO) was added to the solution and the solution was stirred continuously. Within 3-5 minutes a precipitate began to form. After 30 minutes the stirring was discontinued and the mixture was left standing at room temperature until the precipitate had settled to the bottom. The supernatant was removed by aspiration and the precipitate was suspended in enough deionized water to yield 200 ml. This suspension was then heated in a beaker with continuous stirring until the precipitate had completely dissolved after which the beaker was placed in an ice bath and stored overnight in a cold room (4°). The following morning the supernatant was aspirated from the crystals and the crystals were freeze dried. Assay of the crystals proved that the complex contained 2 moles of picolinic acid and 1 mole of zinc [zinc dipicolinate, Zn(PA)2 ].
benefits
Zinc Picolinate is a dietary zinc supplement containing the zinc salt of picolinic acid, that can be used to prevent or treat zinc deficiency, and with immunomodulatory activity. Zinc picolinate appears to have the greatest efficacy in reversing the zinc deficiency of AE and is also absorbed to a higher degree in normal subjects than other zinc supplements.Upon administration, zinc picolinate supplements zinc. As an essential trace element, zinc is of key importance in many biological processes. It plays an important role in the proper functioning of the both the innate and adaptive immune system. Zinc inhibits the production of pro-inflammatory mediators and prevents inflammation. It acts as an antioxidant, prevents oxidative damage and protects cells against DNA damage. Zinc is required for the enzyme activities necessary for cell division, cell growth, and wound healing.
Check Digit Verification of cas no
The CAS Registry Mumber 17949-65-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,9,4 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17949-65:
(7*1)+(6*7)+(5*9)+(4*4)+(3*9)+(2*6)+(1*5)=154
154 % 10 = 4
So 17949-65-4 is a valid CAS Registry Number.
InChI:InChI=1/2C6H5NO2.Zn/c2*8-6(9)5-3-1-2-4-7-5;/h2*1-4H,(H,8,9);/q;;+2/p-2