179555-10-3

Basic information

• Product Name: 2-AMINO-5-CYANO-4-PICOLINE
• Synonyms: 6-Amino-4-methylnicotinonitrile;2-Amino-5-cyano-4-picoline, 6-Amino-4-methylpyridine-3-carbonitrile;2-AMino-5-cyano-4-Methylpyridine;6-amino-4-methyl-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-amino-4-methyl-;2-AMINO-5-CYANO-4-PICOLINE;3-Pyridinecarbonitrile,6-amino-4-methyl-(9CI);6-amino-4-methylpyridine-3-carbonitrile
• CAS NO: 179555-10-3
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15058
• Product Categories: PYRIDINE
• Mol File: 179555-10-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 318.514 °C at 760 mmHg
• Flash Point: 146.432 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.10±0.24(Predicted)
• CAS DataBase Reference: 2-AMINO-5-CYANO-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CYANO-4-PICOLINE(179555-10-3)
• EPA Substance Registry System: 2-AMINO-5-CYANO-4-PICOLINE(179555-10-3)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 179555-10-3(Hazardous Substances Data)

Usage

General Description

2-Amino-5-cyano-4-picoline is a chemical compound with the formula C7H6N4. It is a versatile intermediate with applications in pharmaceuticals, agrochemicals, and other industries. 2-AMINO-5-CYANO-4-PICOLINE is a potential ligand for coordinating metal ions and has proven to be useful in the synthesis of various coordination complexes. Additionally, 2-Amino-5-cyano-4-picoline also serves as a building block in the production of heterocyclic compounds and dyes. It is a valuable chemical with a wide range of potential applications in different fields.

InChI:InChI=1/C7H7N3/c1-5-2-7(9)10-4-6(5)3-8/h2,4H,1H3,(H2,9,10)

Upstream product

• 98198-48-2 2-amino-5-bromo-4-methylpyridine 
• 544-92-3 copper(I) cyanide 
• 107-15-3 ethylenediamine 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 1312556-65-2 7-methylimidazo[1,2-a]pyridine-6-carboxylic acid 
• 720660-12-8 5-(aminomethyl)-4-methylpyridin-2-amine 
• 1224465-02-4 5-methoxycarbonyl-4-methyl-2-hydroxypyridine 
• 66909-35-1 6-chloro-4-methylpyridine-3-carbonitrile 

Relevant articles and documents

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of the formula (I) wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, nematodes, molluscs or representatives of the order Acarina.

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.

PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES

The invention relates to compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the GPR38 receptor.