179694-35-0 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 8 carbon (C), 10 hydrogen (H), 2 fluorine (F), and 2 oxygen (O) atoms.
Explanation
This is the systematic name of the compound, which follows the IUPAC nomenclature rules. The name indicates the presence of an ethane diol (two hydroxyl groups) and a 4-fluorophenyl group attached to the ethane diol.
Explanation
This is an alternative name for the compound, which highlights the chiral center (R) and the presence of a 4-fluorophenyl group attached to a 1,2-ethanediol.
4. Chiral Molecule
Explanation
A chiral molecule is one that has a non-superimposable mirror image. In this case, the compound has a chiral center at the carbon atom bonded to the hydroxyl groups, resulting in two enantiomers (1R and 1S).
Explanation
The (1R) enantiomer is one of the two possible mirror images of the compound. It is of particular interest in medicinal chemistry due to its potential pharmacological properties.
Explanation
The compound is used as a starting material or intermediate in the synthesis of various pharmaceuticals and agrochemicals, taking advantage of its unique structure and reactivity.
7. Toxicological Effects
Explanation
The compound may have toxicological effects, which means it can be harmful to living organisms if not handled properly. This highlights the importance of using appropriate safety measures when working with this compound in laboratory and industrial settings.
Explanation
Due to its potential toxicological effects, it is crucial to handle this compound with care, using proper safety equipment and procedures to minimize the risk of exposure and contamination.
Enantiomer
(1R)-enantiomer
Applications
Building block in the synthesis of pharmaceuticals and agrochemicals
Handling Precautions
Controlled manner in laboratory and industrial settings
Check Digit Verification of cas no
The CAS Registry Mumber 179694-35-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,6,9 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 179694-35:
(8*1)+(7*7)+(6*9)+(5*6)+(4*9)+(3*4)+(2*3)+(1*5)=200
200 % 10 = 0
So 179694-35-0 is a valid CAS Registry Number.
179694-35-0Relevant articles and documents
Structure-Guided Regulation in the Enantioselectivity of an Epoxide Hydrolase to Produce Enantiomeric Monosubstituted Epoxides and Vicinal Diols via Kinetic Resolution
Hou, Xiao-Dong,Hu, Bo-Chun,Hu, Die,Lei, Yu-Qing,Rao, Yi-Jian,Wu, Min-Chen,Zhang, Dong
supporting information, p. 1757 - 1761 (2022/03/16)
Structure-guided microtuning of an Aspergillus usamii epoxide hydrolase was executed. One mutant, A214C/A250I, displayed a 12.6-fold enhanced enantiomeric ratio (E = 202) toward rac-styrene oxide, achieving its nearly perfect kinetic resolution at 0.8 M in pure water or 1.6 M in n-hexanol/water. Several other beneficial mutants also displayed significantly improved E values, offering promising biocatalysts to access 19 structurally diverse chiral monosubstituted epoxides (97.1 - ≥ 99% ees) and vicinal diols (56.2-98.0% eep) with high yields.
Iodine-Initiated Dioxygenation of Aryl Alkenes Using tert-Butylhydroperoxides and Water: A Route to Vicinal Diols and Bisperoxides
Gao, Xiaofang,Lin, Jiani,Zhang, Li,Lou, Xinyao,Guo, Guanghui,Peng, Na,Xu, Huan,Liu, Yi
, p. 15469 - 15480 (2021/11/16)
An environment-friendly and efficient dioxygenation of aryl alkenes for the construction of vicinal diols has been developed in water with iodine as the catalyst and tert-butylhydroperoxides (TBHPs) as the oxidant. The protocol was efficient, sustainable, and operationally simple. Detailed mechanistic studies indicated that one of the hydroxyl groups is derived from water and the other one is derived from TBHP. Additionally, the bisperoxides could be obtained in good yields with iodine as the catalyst, Na2CO3 as the additive, and propylene carbonate as the solvent, instead.
Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents
Pan, Liangkun,Ke, Zhihai,Yeung, Ying-Yeung
supporting information, p. 8174 - 8178 (2021/10/25)
1,2-Diols are extremely useful building blocks in organic synthesis. Hypervalent iodine reagents are useful for the vicinal dihydroxylation of olefins to give 1,2-diols under metal-free conditions, but strongly acidic promoters are often required. Herein, we report a catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts. The conditions are mild and compatible with various functional groups.
