180048-73-1Relevant articles and documents
Synthetic method of firocoxib intermediate
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Paragraph 0049; 0057; 0061-0064, (2021/04/10)
The invention provides a synthetic method of a firocoxib intermediate. The method comprises the steps of carrying out hydroxyl protection, acyl chloride preparation and Friedel-Crafts acylation, and further carrying out a sulfination reaction. The raw materials 2-hydroxy isobutyric acid and bromobenzene are cheap and easily available, and the whole process is concise in step, simple to operate, easy to amplify, high in yield and good in purity. The first three steps adopt a 'one-pot method' reaction, complex post-treatment is not needed, separation and purification are not needed, the next step of reaction is directly carried out, the operation process is greatly simplified, and the production efficiency is improved. In addition, only one solvent is used, the use and recovery of various solvents and the generation of various wastewater and waste gases are avoided, the production cost is greatly reduced, and good industrial application prospects are realized.
Method for preparing firocoxib
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, (2019/11/28)
The invention relates to the technical field of medicines and particularly relates to a method for preparing firocoxib. Raw materials used in the preparation method are conventional reagents in the market, thioanisole which is easily volatized and has str
Synthesis methods of firocoxib and firocoxib intermediate
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Paragraph 0098-0108, (2018/03/26)
The invention relates to the field of medicine synthesis and provides synthesis methods of firocoxib and a firocoxib intermediate. The synthesis method of the firocoxib intermediate takes 4'-bromopropiophenone as a starting raw material and a condition th