180188-64-1

Basic information

• Product Name: (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid methyl ester
• Synonyms: (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid methyl ester
• CAS NO: 180188-64-1
• Molecular Weight: 561.699
• Mol File: 180188-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid methyl ester(180188-64-1)
• EPA Substance Registry System: (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid methyl ester(180188-64-1)

Safety Data

• Hazardous Substances Data: 180188-64-1(Hazardous Substances Data)

Upstream product

• 21685-51-8 D-phenylalanine methyl ester 
• 180088-29-3 (4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoic acid 
• 180088-28-2 ((3E,7E)-4,8,12-Trimethyl-trideca-3,7,11-trienyl)-phosphonic acid diethyl ester 
• 24163-93-7 farnesyl bromide 
• 683-08-9 Diethyl methylphosphonate 
• 4128-17-0 (2E,6E)-farnesyl acetate 

Downstream Products

• 180188-65-2 (R)-2-[(4E,8E)-2-(Diethoxy-phosphoryl)-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino]-3-phenyl-propionic acid 

Relevant articles and documents

Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine

New farnesyl phosphonate derivatives of phenylalanine have been prepared as inhibitors of farnesyl-protein transferase (FPT). Enzyme inhibition studies with bovine brain FPT and rat liver squalene synthase show that compound 3a is a new, potent and selective FPT inhibitor. Moreover, structural modifications from 3a have provided some useful information concerning the key structural subunits necessary for optimum and selective FPT inhibition.