18028-10-9

Basic information

• Product Name: 2-(3-(benzyloxy)-4-methoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide
• CAS NO: 18028-10-9
• Molecular Formula: C₂₆H₂₉NO₅
• Molecular Weight: 435.5122
• Mol File: 18028-10-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 639.4°C at 760 mmHg
• Flash Point: 340.5°C
• Density: 1.15g/cm³
• Vapor Pressure: 3.02E-16mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 2-(3-(benzyloxy)-4-methoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(benzyloxy)-4-methoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide(18028-10-9)
• EPA Substance Registry System: 2-(3-(benzyloxy)-4-methoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide(18028-10-9)

Safety Data

• Hazardous Substances Data: 18028-10-9(Hazardous Substances Data)

Usage

Chemical class

Acetamides

Structure

Complex, containing benzene rings, methoxy groups, and an acetamide functional group

Benzyloxy group

Present in the molecule, influencing its interactions with biological systems

Dimethoxyphenyl group

Present in the molecule, influencing its interactions with biological systems

Potential pharmacological activity

Suggested by its structural features

Potential biological activity

Suggested by its structural features

Subject of interest

For further research and investigation due to its structural features and potential activities

Upstream product

• 5487-33-2 O-benzylhomoisovanillic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 54313-33-6 2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride 
• 621-59-0 isovanillin 
• 100-39-0 benzyl bromide 

Downstream Products

• 75608-42-3 N-[2-(3,4-dimethoxyphenyl)ethyl]-2-(3-hydroxy-4-methoxyphenyl)acetamide 
• 75608-34-3 [2-(3-Benzyloxy-4-methoxy-phenyl)-ethyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine; hydrochloride 
• 41183-13-5 1-(3-benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 919082-49-8 14-(3-acetoxy-4-methoxyphenyl)-3-acetoxy-2,11,12-trimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 919082-37-4 ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate 
• 189083-79-2 14-(3-hydroxy-4-methoxyphenyl)-3-hydroxy-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 475232-29-2 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one 
• 596111-78-3 14-(3-acetoxy-4-methoxyphenyl)-3-acetoxy-2,11,12-trimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 

Relevant articles and documents

Total synthesis of natural and unnatural lamellarins with saturated and unsaturated D-rings

(Chemical Equation Presented) Twenty-eight natural and unnatural lamellarins with either a saturated or an unsaturated D-ring were synthesized according to our developed synthetic route. The key step involved the Michael addition/ring closure (Mi-RC) of the benzyldihydroisoquinoline and α-nitrocinnamate derivatives, which provided the 2-carboethoxypyrrole intermediates in moderate to good yields (up to 78% yield). Subsequent hydrogenolysis/lactonization furnished lamellarins with a saturated D-ring in excellent yields (up to 93% yield). DDQ oxidation of the saturated lamellarin acetates led directly to the corresponding unsaturated analogues in 54-95% yield. In addition, only two steps in our developed strategy require column chromatography.