18036-83-4

Basic information

• Product Name: trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane
• CAS NO: 18036-83-4
• Molecular Formula: C₁₂H₂₂OSi₂
• Molecular Weight: 238.4735
• Mol File: 18036-83-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 244.9°C at 760 mmHg
• Flash Point: 84.3°C
• Density: 0.89g/cm³
• Vapor Pressure: 0.0463mmHg at 25°C
• Refractive Index: 1.467
• CAS DataBase Reference: trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane(CAS DataBase Reference)
• NIST Chemistry Reference: trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane(18036-83-4)
• EPA Substance Registry System: trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane(18036-83-4)

Safety Data

• Hazardous Substances Data: 18036-83-4(Hazardous Substances Data)

Usage

General Description

Trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane is a chemical compound with the molecular formula C15H28OSi2. It is commonly used as a silylating agent in organic synthesis, particularly in the protection of alcohols and phenols. trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane consists of a silicon atom bonded to three methyl groups and a phenyl group, as well as a trimethylsilyloxy group attached to the phenyl ring. Trimethyl{2-[(trimethylsilyl)oxy]phenyl}silane is often used in the modification and functionalization of organic molecules, as well as in the production of various silicone-based materials. It is a versatile and widely utilized chemical with applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 17881-65-1 (2-chlorophenoxy)trimethylsilane 
• 108-95-2 phenol 
• 95-56-7 2-hydroxybromobenzene 
• 1825-62-3 ethyl trimethylsilyl ether 

Downstream Products

• 15288-53-6 o-(trimethylsilyl)phenol 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 33356-45-5 2-(Trimethylsilyl)benzenethiol 
• 497180-98-0 S-(2-trimethylsilylphenyl)-N,N-dimethylaminothiocarbamate 
• 497180-95-7 O-(2-trimethylsilylphenyl)-N,N-dimethylaminothiocarbamate 
• 101-84-8 diphenylether 
• 609-46-1 phenol-2-sulfonic acid 
• 40182-17-0 chlorure d'o-acetoxybenzenesulfonyle 
• 141765-59-5 o-acetoxybenzenesulfonate de trimethylsilyle 
• 1253786-03-6 2-(tert-butyl)-2,3-dihydro-3-phenyl-1,2-benzoisoxazole 
• 1276113-19-9 2-(trimethylsilyl)phenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 

Relevant articles and documents

2-(Trimethylsilyl)phenyl Trimethylsilyl Ethers as Stable and Readily Accessible Benzyne Precursors

Stable 2-(trimethylsilyl)phenyl trimethylsilyl ethers, readily obtained from the corresponding halogenated phenols in two steps, were identified as novel benzyne precursors. These species were converted to benzynes by a domino reaction of O-desilylation,

Interaction of alkoxides. XVIII. Utilitization of the complex base from alkyllithium and potassium alkoxides in the dimetallation of phenol, thiophenol, o-, m- and p-cresol

Successful O- and ortho-ring metallation of phenol and side chain metallation in o-cresol has been achieved by use of a mixture of two molar equivalents of n-butyllithium, one molar equivalent of potassium t-butoxide and two molar equivalents of N,N,N',N'-tetramethylethylene diamine in hexane.Poor results were obtained with m-cresol, thiophenol and p-cresol. m-Cresol was effectively dimetallated with a mixture of two molar equivalents of tBuOK and two molar equivalents of nBuLi*TMEDA.The effectiveness of another type of complex base based on 2-ethylhexyllithium (EhexLi) and potassium alkoxides has been also investigated, especially in respect of the influence of the concentration and the ctructure of the alkoxide used.With a complex base from EhexLi and 3 equivalents of potassium 3-methyl-3-pentoxide phenol was successfuly dimetallated even in the absence of TMEDA.Thus, the enhanced reactivity of a complex base containing a higher concentration of a more branched potassium alkoxide over that of previously used complex bases has been confirmed.

Reactions of o-Lithio-lithiumphenolate and o-Lithio-N-methyl-lithiumanilide with Halides of Phosphorus, Arsenic and Silicon

The title compounds and chlorides of the type ClERn (E=P, As, Si) react smoothly in a molecular ratio of 1:2 to give the corresponding disubstituted phenole and N-methylaniline derivatives, respectively.Attempts with an 1:1 ratio show different results de