180868-81-9Relevant articles and documents
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: Novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity
Gagliardi, Stefania,Nadler, Guy,Consolandi, Emanuela,Parini, Carlo,Morvan, Marcel,Legave, Marie-N?elle,Belfiore, Pietro,Zocchetti, Andrea,Clarke, Geoffrey D.,James, Ian,Nambi, Ponnal,Gowen, Maxine,Farina, Carlo
, p. 1568 - 1573 (1998)
The vacuolar H+-ATPase (V-ATPase), located on the ruffled border of the osteoclast, is a proton pump which is responsible for secreting the massive amounts of protons that are required for the bone resorption process. With the aim to identify n