18097-52-4

Basic information

• Product Name: 2-AMINO-5-CHLOROBENZOPHENONE OXIME
• Synonyms: 2-AMINO-5-CHLOROBENZOPHENEONE OXIME;2-AMINO-5-CHLOROBENZOPHENONE OXIME;AKOS 90376;TIMTEC-BB SBB003174;(2-amino-5-chlorophenyl)phenyl-methanonoxime;2-amino-5-chlorobenzophenoneoxime,mixtureofsynandantiisomers;2-Amino-5-chlorobenzophenoneα-oxime-,(Z)-;Mixtureofsyn-andanti-isomeres
• CAS NO: 18097-52-4
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.69
• EINECS: 241-999-5
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 18097-52-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 434.9°Cat760mmHg
• Flash Point: 216.8°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 2.47E-08mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(18097-52-4)
• EPA Substance Registry System: 2-AMINO-5-CHLOROBENZOPHENONE OXIME(18097-52-4)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 18097-52-4(Hazardous Substances Data)

Usage

Description

2-AMINO-5-CHLOROBENZOPHENONE OXIME is a yellow crystalline powder with a melting point of 98-100°C. It is an important chemical intermediate used in the synthesis of various psychotherapeutic agents and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-CHLOROBENZOPHENONE OXIME is used as a chemical intermediate for the synthesis of psychotherapeutic agents such as chlordiazepoxide (C327050) and its metabolites. It plays a crucial role in the production of these medications, which are used to treat anxiety, insomnia, and other related conditions.
Additionally, it is used as an intermediate in the preparation of Oxazolam, another drug with psychotherapeutic properties. The compound's chemical structure allows for further modification and synthesis of these pharmaceuticals, making it a valuable component in the development of new treatments for various mental health disorders.

Reference

R. Liao, Synthetic method of Oxazolam drug intermediate 2-amino-5-chlorobenzophenone, Patent CN105461576A S. Nakanishi, W. E. Barth, Process for preparing 6-chloromethyl-4-phenylquinazoline-3-oxide and intermediates therefor, Patent US3932325A

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3957, 1965 DOI: 10.1021/jo01022a519

InChI:InChI=1/C13H11ClN2O/c14-10-6-7-12(15)11(8-10)13(16-17)9-4-2-1-3-5-9/h1-8,17H,15H2/b16-13+

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 

Downstream Products

• 71525-69-4 Maleinsaeuremono-N<4-chlor-2-(oximinophenyl-methyl)phenyl>-amid 
• 5958-24-7 6-chloro-2-chloromethyl-4-phenylquinazoline-3-oxide 
• 4765-61-1 2-methyl-4-phenyl-6-chloroquinazoline 
• 1824-70-0 2-amino-5-chlorobenzhydrylamine 
• 41608-99-5 6-chloro-4-phenyl-1,2,3-benzotriazine 3-oxide 
• 17977-76-3 2-chloro-N-{4-chloro-2-[(hydroxyimino)(phenyl)methyl]phenyl}acetamide 

Relevant articles and documents

NOVEL 3-SUBSTITUTED-1,4-BENZODIAZEPINES

The present invention relates to compounds of formula (I). The invention also relates to methods for preparing the compounds and their uses as CCK receptor ligands and CCK antagonists.