180977-37-1

Basic information

• Product Name: 4-nitro-2-(1-naphthyl)benzoic acid
• Synonyms: 4-nitro-2-(1-naphthyl)benzoic acid
• CAS NO: 180977-37-1
• Molecular Weight: 293.279
• Mol File: 180977-37-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-nitro-2-(1-naphthyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitro-2-(1-naphthyl)benzoic acid(180977-37-1)
• EPA Substance Registry System: 4-nitro-2-(1-naphthyl)benzoic acid(180977-37-1)

Safety Data

• Hazardous Substances Data: 180977-37-1(Hazardous Substances Data)

Upstream product

• 180977-38-2 4-nitro-2-(1-naphthyl)benzoic acid methyl ester 
• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 100959-22-6 methyl 2-bromo-4-nitrobenzoate 
• 13922-41-3 1-Naphthylboronic acid 
• 703-55-9 1-naphthylmagnesiumbromide 

Downstream Products

• 180977-42-8 4-nitro-2-naphthylbenzoyl-leucine methyl ester 
• 180977-39-3 N-[4-nitro-2-(1-naphthyl)benzoyl]-methionine methyl ester 
• 191102-99-5 (S)-2-(4-Amino-2-naphthalen-1-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester 
• 180977-40-6 N[4-[N-[2(R)-(tert-butoxycarbonyl)amino-3-(triphenylmethyl)thio]propyl]amino-2-(1-naphthyl)benzoyl]-methionine methyl ester 
• 478909-61-4 (S)-2-(4-Amino-2-naphthalen-1-yl-benzoylamino)-4-methyl-pentanoic acid methyl ester 
• 180977-43-9 (S)-2-[4-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid methyl ester 
• 1613315-69-7 C₂₇H₂₆N₄O₄S₂ 
• 1613316-26-9 C₃₀H₃₂N₄O₄S₂ 
• 1613316-14-5 C₂₅H₂₈N₂O₃S 
• 1613316-20-3 C₄₉H₄₆N₄O₄S₂ 
• 1613316-08-7 C₂₅H₂₆N₂O₅S 

Relevant articles and documents

Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed as farnesyltransferase (FTase) inhibitors (FTIs) by replacing AA with o-aryl or o-heteroaryl substituted p-hydroxy- or p-aminobenzoic acid, while maintaining the replacement of C with 1,4-benzodioxan-2-ylmethyl or 2-amino-4- thiazolylacetyl residue as in previous CAAX mimetics. Both FTase inhibition and antiproliferative effect were showed by two thiazole derivatives, namely those with 1-naphthyl (10 and 10a) or 3-furanyl (15 and 15a) in the central spacer, and by the benzodioxane derivative with 2-thienyl (6 and 6a) in the same position. Accumulation of unprenylated RAS was demonstrated in cells incubated with 15a. Consistently with FTIs literature, such results delineate the biaryl scaffold not only as a spacer but also as a sensible area of these mimetic molecules, where modifications at the branching aromatic ring are not indifferent and should be matter of further investigation.

Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

In this paper we describe the synthesis of a family of CAAL peptidomimetics as GGTase-I inhibitors. These inhibitors lack the central dipeptide AA in the key CAAL carboxy terminal sequence of geranylgeranylated proteins and are more selective for GGTase-I over FTase. In whole cells, these compounds are very potent inhibitors of the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras. One derivative, GGTI-298, inhibited cell division by blocking cells in the G1 phase of the cell cycle.