180995-12-4Relevant articles and documents
Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines
Khoje, Abhijit Datta,Gundersen, Lise-Lotte
scheme or table, p. 523 - 525 (2011/02/28)
The influence of substituents at C-3 of 2,4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P)2PdCl2-catalyzed Stille coupling between 2-furyl(tributyl)tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino group at C-3, and the selectivity is totally reversed when the amino group is exchanged for a nitro substituent.
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors
Dai, Yujia,Hartandi, Kresna,Soni, Niru B.,Pease, Lori J.,Reuter, David R.,Olson, Amanda M.,Osterling, Donald J.,Doktor, Stella Z.,Albert, Daniel H.,Bouska, Jennifer J.,Glaser, Keith B.,Marcotte, Patrick A.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.
, p. 386 - 390 (2008/04/03)
Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted k
Novel kinase inhibitors
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Page/Page column 18, (2008/06/13)
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.