181125-99-5

Basic information

• Product Name: 4-[4-(6-bromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide
• CAS NO: 181125-99-5
• Molecular Weight: 478.347
• Mol File: 181125-99-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-(6-bromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(6-bromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide(181125-99-5)
• EPA Substance Registry System: 4-[4-(6-bromo-2-oxo-2H-chromen-3-yl)-thiazol-2-ylamino]-benzenesulfonamide(181125-99-5)

Safety Data

• Hazardous Substances Data: 181125-99-5(Hazardous Substances Data)

Upstream product

• 2199-93-1 3-Acetyl-6-bromo-chromen-2-one 
• 1718-39-4 (4-aminosulfonylphenyl)thiourea 
• 106578-01-2 6-bromo-3-(2-bromoacetyl)-2H-chromen-2-one 

Relevant articles and documents

Dual evaluation of some novel 2-amino-substituted coumarinylthiazoles as anti-inflammatory-antimicrobial agents and their docking studies with COX-1/COX-2 active sites

Synthesis of total eighteen 2-amino-substituted 4-coumarinylthiazoles including sixteen new compounds (3a-o and 5b) bearing the benzenesulfonamide moiety is described in the present report. All the synthesized target compounds were examined for their in vivo anti-inflammatory (AI) activity and in vitro antimicrobial activity. Results revealed that six compounds (3d, 3f, 3g, 3h, 3j and 3n) exhibited pronounced anti-inflammatory activity comparable to the standard drug indomethacin. AI results were further confirmed by the docking studies of the most active (3n) and the least active compound (3a) with COX-1 and COX-2 active sites. In addition, most of the compounds exhibited moderate antimicrobial activity against Gram-positive bacteria as well as fungal yeast, S. cervisiae. Comparison between 3 and 5 indicated that incorporation of additional substituted pyrazole nucleus into the scaffold significantly enhanced AI activity.