18158-44-6

Basic information

• Product Name: 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI)
• Synonyms: 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI);4-BiphenylaMine,4'-Methoxy-N,N-diMethyl-;4'-Methoxy-N,N-dimethylbiphenyl-4-amine
• CAS NO: 18158-44-6
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227
• Mol File: 18158-44-6.mol
• Article Data: 42

Chemical Properties

• Melting Point: 156-157℃
• Appearance: /
• CAS DataBase Reference: 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI)(18158-44-6)
• EPA Substance Registry System: 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI)(18158-44-6)

Safety Data

• Hazardous Substances Data: 18158-44-6(Hazardous Substances Data)

Usage

General Description

4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI) is a chemical compound with the molecular formula C15H17NO. It is a derivative of biphenylamine, containing a methoxy group and two dimethyl groups. 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI) is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used as a rubber antioxidant and a stabilizer for PVC. 4-Biphenylamine, 4'-methoxy-N,N-dimethyl- (8CI) is considered to be a hazardous substance, and proper safety precautions should be taken when handling it.

Upstream product

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• 104-92-7 1-bromo-4-methoxy-benzene 
• 1123247-11-9 potassium (4-N,N-dimethylaminophenyl)dimethylsilanolate 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 
• 696-62-8 para-iodoanisole 
• 97302-05-1 di-4-methoxyphenylzinc 
• 93296-10-7 (4-(dimethylamino)phenyl)zinc(II) chloride 
• 698-69-1 4-chloro-N,N-dimethylaniline 

Downstream Products

• 613-37-6 4-methoxylbiphenyl 
• 446311-34-8 2-(4'-methoxy-[1,1^,-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

CuPd nanoparticles as a catalyst in carbon-carbon cross-coupling reactions by a facile oleylamine synthesis

CuPd bi-metallic nanoparticles were synthesized in oleylamine without the use of additional surfactants, ligands, or reducing agents. The alloyed nanoparticles showed high catalytic activity in Suzuki cross-coupling reactions with excellent turnover number (6000) and turnover frequency of 72:000 h-1 under microwave irradiation. These nanoparticles were successfully utilized in a Suzuki coupling reaction with a diverse range of functionalized substrates. The catalyst also demonstrated multiple recyclability for Suzuki coupling reactions. The CuPd nanoparticles have also probed the utility in other cross-coupling reactions such as Heck and Sonogashira coupling reactions. According to the XPS data, two oxidation states of each metal exist on the surface of the nanoparticle. This is advantageous especially for Sonogashira cross-coupling reactions because having Cu+ present on the surface of the catalyst eliminates the need for a copper salt to stabilize the alkyne during the reaction.

Visible-Light-Mediated Late-Stage Sulfonylation of Anilines with Sulfonamides

A visible-light-mediated late-stage sulfonylation of anilines with sulfonamides under simple reaction conditions is presented. Various primary or secondary sulfonamides including several pharmaceuticals were incorporated successfully via N–S bond activati

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Organozinc-mediated direct cross-coupling under microwave irradiation

We report a direct cross-coupling reaction between (het)aryl pivalates/tosylates and di(het)arylzinc species in 2-methyltetrahydrofuran/N-methyl pyrrolidone (1:1), which occurs via C–O bond cleavage under microwave irradiation. The reaction takes place smoothly in short reaction times without the addition of any catalyst or ligand. The reaction is suitable for a broad scope of substrates and exhibits good functional group compatibility, utilizes a simple work-up procedure, and gives the desired products in high purity.