181780-45-0

Basic information

• Product Name: [5-(2-cyano-ethylamino)-pentyl]-carbamic acid tert-butyl ester
• Synonyms: [5-(2-cyano-ethylamino)-pentyl]-carbamic acid tert-butyl ester
• CAS NO: 181780-45-0
• Molecular Weight: 255.36
• Mol File: 181780-45-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [5-(2-cyano-ethylamino)-pentyl]-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [5-(2-cyano-ethylamino)-pentyl]-carbamic acid tert-butyl ester(181780-45-0)
• EPA Substance Registry System: [5-(2-cyano-ethylamino)-pentyl]-carbamic acid tert-butyl ester(181780-45-0)

Safety Data

• Hazardous Substances Data: 181780-45-0(Hazardous Substances Data)

Upstream product

• 51644-96-3 5-tert-butoxycarbonylamino-1-aminopentane 
• 107-13-1 acrylonitrile 

Relevant articles and documents

Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library

A library of 24 derivatives designed by combining two natural products-derived fragments was prepared and tested to determine their anticancer potential in HT29 colon cancer cells. All library members inhibit cell proliferation as measured by MTT mitochondrial functional assay, with IC 50 values in the 1-100 μM range. Entry 1b caused apoptotic EGFR-mediated intracellular signaling. Thus, polyamino-quinones emerged as readily accessible and easily diversified scaffolds for anticancer lead discovery.