18184-79-7

Basic information

• Product Name: 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione
• Synonyms: 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione
• CAS NO: 18184-79-7
• Molecular Weight: 252.272
• Mol File: 18184-79-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione(18184-79-7)
• EPA Substance Registry System: 6-phenethyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione(18184-79-7)

Safety Data

• Hazardous Substances Data: 18184-79-7(Hazardous Substances Data)

Upstream product

• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 64-04-0 phenethylamine 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 4664-00-0 2,3-pyridinedicarboximide 

Downstream Products

• 120348-03-0 5,12b-dihydro-12b-phenylpyrido<2',3':3,4>pyrrolo<2,1-a>isoquinolin-8(6H)-one 
• 120347-98-0 5,6-dihydro-5-hydroxy-6-(2-phenyl-ethyl)-pyrrolo[3,4-b]pyridin-7-one 
• 120347-90-2 6,7-dihydro-7-hydroxy-6-(2-phenylethyl)pyrrolo<3,4-b>pyridin-5-one 
• 120347-94-6 6,7-dihydro-7-hydroxy-7-phenyl-6-(2-phenylethyl)pyrrolo<3,4-b>pyridin-5-one 

Relevant articles and documents

Efficient conversion of acids and esters to amides and transamidation of primary amides using OSU-6

OSU-6, an MCM-41 type hexagonal mesoporous silica with strong Bronsted acid properties, has been used to promote the high-yield conversion of carboxylic acids and esters to carboxamides as well as transamidations of primary amides in a one-pot solventless approach. A metal-free heterogeneous catalyst that promotes all of these processes has not been previously reported. OSU-6 enables these transformations to proceed in shorter times and at lower temperatures for a broad range of substrates. An added benefit is that the catalyst can be recycled and reused multiple times without significant loss of activity.

Regioselective Formation of Hydroxy Lactams from Pyridine-2,3-dicarboximides and their Cyclodehydration to Pyridopyrrolo-fused Heterocyclic Systems

Grignard reactions of pyridine-2,3-dicarboximides involve attack at the carbonyl group closer to the pyridine nitrogen atom to give 7-hydroxypyrrolopyridin-5(7H)-one derivatives.Reduction of the same imides with sodium borohydride gives mixtures of regiosomeric hydroxy lactams, in which the 7-hydroxypyrrolopyridin-5-ones are the major components.Hydroxy lactams derived by either of these two methods from pyridine-2,3-dicarboximides containing N-benzyl, N-2-phenylethyl, N-2-(indol-3-yl)ethyl, or N-biphenyl-2-yl substituents are cyclised by heating in trifluoroacetic or polyphosphoric acid to give derivatives of new pyridopyrrolo-fused heterocyclic systems.