1820574-78-4Relevant articles and documents
Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach
Murphy, Rebecca A.,Chen, Anthony Y.,Nair, Sajiv K.,Gallego, Gary M.,Sach, Neal W.,Smith, Graham
, p. 5588 - 5591 (2016)
We describe herein a diastereoselective approach to access substituted-4-aminopiperidines from pyridine precursors. This methodology has successfully been applied to synthesize 2-alkyl substrates as well as more complex molecular entities of interest to the pharmaceutical industry.