18212-83-4

Basic information

• Product Name: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone
• Synonyms: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone
• CAS NO: 18212-83-4
• Molecular Weight: 254.285
• Mol File: 18212-83-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone(18212-83-4)
• EPA Substance Registry System: 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-phenylethanone(18212-83-4)

Safety Data

• Hazardous Substances Data: 18212-83-4(Hazardous Substances Data)

Upstream product

• 57744-67-9 6-iodo-1,4-benzodioxane 
• 201230-82-2 carbon monoxide 
• 100-44-7 benzyl chloride 
• 583860-52-0 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-hydroxyethan-1-one 
• 493-09-4 benzo-1,4-dioxane 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 130396-97-3 6-(α-methylamino-ω-phenylacetyl)-1,4-benzodioxane 
• 130396-95-1 6-(α-formylamino-ω-phenylacetyl)-1,4-benzodioxane 

Relevant articles and documents

Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes

The palladium-catalyzed α-arylation of ketones with readily available nitroarenes and nitroheteroarenes provides access to useful α-aryl and α-heteroaryl ketones. The use of the Pd/ BrettPhos catalysts was critical to achieve high efficiency for these transformations, whereas other catalysts led to decreased yields or no conversions. The intramolecular type substrate was also applied in this methodology and gave a chromone derivative. Polyaromatic carbonyl compounds can be easily obtained by multicomponent tandem reactions, via nucleophilic aromatic substitution (SNAr) or cross-coupling reaction followed by this denitrative arylation. Kinetic experiments show that the electronic effect of nitrobenzenes has a greater effect on the reaction rate than the electronic effect of ketones.

Arylation of α-pivaloxyl ketones with arylboronic reagents via Ni-catalyzed sp3 C-O activation

A Suzuki-Miyaura coupling of α-pivaloxyl ketones via Ni-catalyzed sp3 C-O activation to produce α-aryl ketones is developed. This study offers a convenient method to construct α-arylation products from readily available α-hydroxyl carbonyl compounds.