182621-75-6

Basic information

• Product Name: (R)?2?bromo?1?(4′?chlorophenyl)ethanol
• Synonyms: (R)?2?bromo?1?(4′?chlorophenyl)ethanol
• CAS NO: 182621-75-6
• Molecular Weight: 235.508
• Mol File: 182621-75-6.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(182621-75-6)
• EPA Substance Registry System: (R)?2?bromo?1?(4′?chlorophenyl)ethanol(182621-75-6)

Safety Data

• Hazardous Substances Data: 182621-75-6(Hazardous Substances Data)

Upstream product

• 6314-52-9 2-bromo-1-(4-chlorophenyl)ethanol 
• 22651-87-2 cyclohexanecarboxylic acid anhydride 
• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 108-05-4 vinyl acetate 
• 1073-67-2 4-vinylbenzyl chloride 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 536-38-9 4-chlorobenzoylmethyl bromide 

Downstream Products

• 6314-62-1 C₁₅H₁₆ClNO 
• 2788-86-5 (R)-2-(4-chlorophenyl)oxirane 

Relevant articles and documents

Chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols

In this study, chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols was achieved with high selectivity. Irrespective of the electronic nature and the substitution patterns on the aromatic rings, a variety of substrates were suitable for this reaction. The branched acyl component was considered to be optimal for obtaining high s-values. The transition state of the reaction was proposed based on the absolute configuration of the obtained product.

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%).

Integration of multiple active sites on large-pore mesoporous silica for enantioselective tandem reactions

Facile construction of a multifunctional heterogeneous catalyst through the assembly of Au/carbene and chiral ruthenium/diamine dual complexes in large-pore mesoporous silica was developed. This enables an efficient one-pot hydration-asymmetric transfer hydrogenation enantioselective tandem reaction of haloalkynes, affording chiral halohydrins with up to 99% enantioselectivity. Combined multifunctionalities, such as substrate-promoted silanol-functionality, BF4? anion-bonding gold/carbene and covalent-bonding chiral ruthenium/diamine active centers, contributed cooperatively to the catalytic performance.