18277-20-8

Basic information

• Product Name: 7,9-Hexadecadiyne
• CAS NO: 18277-20-8
• Molecular Formula: C16H26
• Molecular Weight: 218.382
• Mol File: 18277-20-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 7,9-Hexadecadiyne(CAS DataBase Reference)
• NIST Chemistry Reference: 7,9-Hexadecadiyne(18277-20-8)
• EPA Substance Registry System: 7,9-Hexadecadiyne(18277-20-8)

Safety Data

• Hazardous Substances Data: 18277-20-8(Hazardous Substances Data)

Upstream product

• 2063-19-6 4-bromo-2-methylbut-3-yn-2-ol 
• 81438-46-2 1-iodooct-1-yne 
• 932-88-7 1-iodo-2-phenylethyne 
• 591-50-4 iodobenzene 
• 64531-26-6 1-chloro-1-octyne 
• 1066-54-2 trimethylsilylacetylene 
• 629-05-0 n-octyne 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 54502-24-8 copper(I) hexylacetylenide 
• 4559-70-0 Diphenylphosphine oxide 
• 552-16-9 ortho-nitrobenzoic acid 
• 100-51-6 benzyl alcohol 
• 536-74-3 phenylacetylene 

Downstream Products

• 7778-87-2 n-propyl heptanoate 
• 1203801-51-7 C₃₂H₅₀O₃ 
• 1228507-60-5 2,5-dihexyl-1-phenyl-1H-pyrrole 

Relevant articles and documents

C?C Bond Formation of Benzyl Alcohols and Alkynes Using a Catalytic Amount of KOtBu: Unusual Regioselectivity through a Radical Mechanism

We report a C?C bond-forming reaction between benzyl alcohols and alkynes in the presence of a catalytic amount of KOtBu to form α-alkylated ketones in which the C=O group is located on the side derived from the alcohol. The reaction proceeds under thermal conditions (125 °C) and produces no waste, making the reaction highly atom efficient, environmentally benign, and sustainable. Based on our mechanistic investigations, we propose that the reaction proceeds through radical pathways.

Room-Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides

An efficient procedure for the synthesis of alkynylphosphine oxides based on the oxidative alkynylation of secondary phosphine oxides with copper acetylides was developed. Activation with molecular oxygen in the presence of either a mixture of 1,2-dimethylimidazole and triethylamine or N-methylimidazole alone enabled the formal umpolung of the poorly nucleophilic copper acetylides, which were coupled with phosphine oxides under remarkably mild conditions. Notable features of this procedure are the availability of the starting materials, its user-friendliness, and its mild conditions, which allow the synthesis of complex alkynylphosphine oxides.

Copper(II)-Promoted, One-Pot Conversion of 1-Alkynes with Anhydrides or Primary Amines to the Respective 2,5-Disubstituted Furans or Pyrroles under Microwave Irradiation Conditions

Furans and pyrroles are prepared from 1-alkynes by using a Cu(II)-promoted, one-pot, microwave irradiation method. Glaser coupling of 1-alkynes and cyclization of the resulting 1,3-diyne in the presence of an anhydride or a primary amine results in the formation of the respective 2,5-diaryl- or 2,5-dialkyl-substituted furans and pyrroles.