18305-60-7

Basic information

• Product Name: Di-tert-butyl Maleate
• Synonyms: 3-Oxetanol,8-ethynyl-;Bis(2-methyl-2-propanyl)(2Z)-2-butenedioate;2-Butenedioic acid (2Z)-, bis(1,1-dimethylethyl) ester
• CAS NO: 18305-60-7
• Molecular Formula: C₁₂H₂₀O₄
• Molecular Weight: 228.2848
• EINECS: -0
• Mol File: 18305-60-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 64-65 °C
• Boiling Point: 273.2±13.0 °C(Predicted)
• Appearance: /
• Density: 1.004±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Di-tert-butyl Maleate(CAS DataBase Reference)
• NIST Chemistry Reference: Di-tert-butyl Maleate(18305-60-7)
• EPA Substance Registry System: Di-tert-butyl Maleate(18305-60-7)

Safety Data

• Hazardous Substances Data: 18305-60-7(Hazardous Substances Data)

Usage

Description

Di-tert-butyl Maleate is an organic compound that belongs to the class of dicarboxylic acid derivatives. It is characterized by its molecular structure, which includes a maleate backbone with two tert-butyl groups attached to it. This unique structure endows Di-tert-butyl Maleate with specific chemical properties and reactivity, making it a valuable intermediate in the synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
Di-tert-butyl Maleate is used as a reactant in the synthesis of J-104,118, a novel and potent inhibitor of squalene synthase. This application is significant because squalene synthase is a key enzyme in the biosynthesis of cholesterol, and its inhibition can lead to the development of new therapeutic strategies for treating hypercholesterolemia and other cholesterol-related conditions.

Upstream product

• 67-56-1 methanol 
• 110-16-7 maleic acid 
• 115-11-7 isobutene 
• 100-42-5 styrene 
• 35059-50-8 t-butyl diazoacetate 
• 49653-47-6 tert-butyl 2,2-dichloroacetate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 591-49-1 1-methylcyclohex-1-ene 
• 95-13-6 1-indene 
• 98-83-9 isopropenylbenzene 
• 22136-61-4 isopropyl diazoacetate 
• 63254-54-6 cyclohexyl diazoacetate 
• 167693-38-1 adamantan-2-yl diazoacetate 
• 623-73-4 diazoacetic acid ethyl ester 

Downstream Products

• 103738-77-8 (3S,4S)-5-Phenyl-3,4-dihydro-2H-pyrrole-3,4-dicarboxylic acid di-tert-butyl ester 
• 97719-37-4 2-Phenylsulfanyl-succinic acid di-tert-butyl ester 
• 166518-40-7 3-tert-Butoxycarbonyl-pentanedioic acid benzyl ester tert-butyl ester 
• 159528-25-3 (S)-di-tert-butyl-2-phenylsuccinate 

Relevant articles and documents

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Carboxylic acid production of tertiary butyl

PROBLEM TO BE SOLVED: To provide a process for producing a carboxylic acid tert-butyl ester industrially advantageously.SOLUTION: The process for producing a carboxylic acid tert-butyl ester includes reacting compounds represented by formula (1) and formula (2) (wherein Y denotes a 1-20C alkoxy group) with isobutene in the presence of an acid catalyst and at normal pressure by using a mixed solvent containing an aromatic hydrocarbon.

Cyclopropanation of olefins with diazo compounds catalyzed by a dicopper-substituted silicotungstate [γ-H2SiW 10O36Cu2(μ-1,1-N3) 2]4-

The dicopper-substituted γ-Keggin silicotungstate (TBA) 4[γ-H2SiW10O36Cu 2II(μ-1,1-N3)2] (I, TBA = tetra-n-butylammonium) could act as an efficient precatalyst for the chemoselective cylopropanation of olefins with diazo compounds. Various kinds of olefins were efficiently converted to the corresponding cyclopropane derivatives in good yields.